Umbilical Cord Stem Cell Lysate: A New Biologic Injection for Treatment of Temporomandibular Joint Inflammation

Progressive degenerative diseases that affect the TMJ, such as osteoarthritis (OA), juvenile idiopathic arthritis (JIA), and idiopathic condylar resorption (ICR), are characterized by ongoing loss of articular fibrocartilage, subchondral bone remodeling, and synovitis.1 These structures can be preserved by reducing inflammation and thereby slowing the progressive catabolic cellular processes underlying the pathogenesis of these conditions.1 Given that mesenchymal stem cells and their derivatives have now been employed in the treatment of numerous systemic pro-inflammatory conditions with promising outcomes, the goal of this study was to investigate the anti-inflammatory effects of human umbilical cord perivascular mesenchymal cells (HUCPVCS) and a cell lysate (CL) derived therefrom in an established hind-paw model of carrageenan-induced inflammation, then further evaluate their anti-inflammatory potential in a model of temporomandibular joint inflammation.2
Source: Journal of Oral and Maxillofacial Surgery - Category: ENT & OMF Authors: Source Type: research