010 Innate and adaptive immunity to Staphylococcus aureus contribute to the development of atopic dermatitis-like skin inflammation

Atopic dermatitis (AD) is an inflammatory dermatosis associated with Staphylococcus aureus (S. aureus) dysbiosis. The immunological mechanisms by which S. aureus contributes to AD remain poorly characterized. We developed a mouse model of AD-like skin inflammation induced by repeated applications of different clinical strains of S. aureus, to explore the role of innate and adaptive immunity in AD. The intensity of the S. aureus-induced AD-like skin inflammation depended on the clinical strain and required the activation of the S.

Source: Journal of Investigative Dermatology - October 1, 2021 Category: Dermatology Authors: C. Braun, C. Badiou, P. Bouschon, V. Patra, W. van Wamel, M. Iwata, S. Nakajima, T. Henry, B. Horvat, F. Vandenesh, J. Nicolas, G. Lina, A. Nosbaum, M. Vocanson Source Type: research