Measuring serum prothrombin in patients treated with warfarin or direct oral anticoagulants

CONCLUSIONS: Warfarin and DOAC led to increase in serum prothrombin concentration The reason is that DOAC decreases prothrombin recruitment during fibrin clot formation, while warfarin leads to the accumulation of inactive prothrombin, which have a decreased number of Gla residues.PMID:34599901 | DOI:10.1016/j.cca.2021.09.023

Source: International Journal of Clinical Chemistry - October 2, 2021 Category: Chemistry Authors: Akira Kondo Hirokazu Kondo Yoshihisa Nakagawa Hideki Kameyama Hiroyuki Ito Daiki Shimomura Hachiro Yamanishi Noriko Hatanaka Yoshikazu Yamamoto Eri Iwai-Kanai Shuji Matsuo Source Type: research