Life in the present tense

It was the cards I noticed first this morning. Each one neatly placed on the windowsill. Carefully butted up against the thin line of mastic securing glass into frame; they were spaced almost exactly it seemed, but without the benefit of a ruler I couldn’t be sure. They ran in order, Hearts, then Spades, Diamonds and finally Clubs; each suit starting Ace’s low. You were moving slowly, gathering them up into a neat stack and beginning to lay them out again. I watched you for a while before going to the kitchen to make the first of many cups of tea. The kettle boiled, I poured water into two mugs on top of the tea bags and splashed in milk. A quick stir, the bags were fished out and dropped on a ‘save the teabag’ dish bought as a gift in Harrods on a long-forgotten trip. I took one mug into the sitting room and placed it to the side of the spread, avoiding your carefully orchestrated movements. Card out, card placed, card adjusted for spacing. Card out, card placed, card adjusted for spacing. “There’s a cup of tea here for you Dad”, I spoke the words quietly and without urgency. Any urgency would upset your routine and you would become distressed. “Frish hand you” You smiled at me when you spoke, a gentle smile that touched every part of your face and illuminated your eyes. I understood what you were saying even though the words didn’t make sense, and I smiled back touching you on the arm as I did so before turning awa...
Source: The Hysterectomy Association - Category: OBGYN Authors: Tags: Fiction alzheimers short story Source Type: news

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Bioorg Chem. 2021 Nov 18;118:105493. doi: 10.1016/j.bioorg.2021.105493. Online ahead of print.ABSTRACTMonoamine oxidase (EC 1.4.3.4, MAO) is a flavin adenine dinucleotide-containing flavoenzyme located on the outer mitochondrial membrane and catalyzes the oxidative deamination of monoaminergic neurotransmitters and dietary amines. MAO exists in humans as two isoenzymes, hMAO-A and hMAO-B, which are distinguished by their tertiary structures, preferred substrates and inhibitors, and selective inhibition of these isoenzymes are used in the treatment of different diseases such as Alzheimer's, Parkinson's and depression. In th...
Source: Bioorganic Chemistry - Category: Chemistry Authors: Source Type: research
Biochem Soc Trans. 2021 Nov 23:BST20210719. doi: 10.1042/BST20210719. Online ahead of print.ABSTRACTNeurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, pose an increasingly severe burden for individuals and society in an ageing population. The causes and mechanisms of the diseases are poorly understood and as yet there are no effective treatments. Some of the molecular complexes involved in degeneration have been identified and electron microscopy has provided an essential tool in the investigations. The focus of this review is to show how electron microscopy has contributed historically to the...
Source: Biochemical Society Transactions - Category: Biochemistry Authors: Source Type: research
CONCLUSION: The deficiency of vitamins in the body causes various neurological disorders like Alzheimer's disease, Parkinson's disease, Huntington's disease, and depression. We have discussed the role of vitamins in neurological disorders and the normal human body. Depression is linked to a deficiency of vitamin-C and vitamin B. In the case of Alzheimer's disease, there is a lack of vitamin-B1, B12, and vitamin-A, which results in Aβ-plaques. Similarly, in Parkinson's disease, vitamin-D deficiency leads to a decrease in the level of dopamine, and imbalance in vitamin D leads to accumulation of synuclein. In MS, Vitami...
Source: CNS and Neurological Disorders Drug Targets - Category: Drugs & Pharmacology Authors: Source Type: research
This study nicely illustrates the importance of the cellular metabolic state of myeloid cells: it highlights that not only the availability of glucose, but also its channeling into different pathways (glycolysis versus glycogen synthesis) contributes to maintaining proper myeloid function. On the Ability of Redundant Blood Vessels to Lower Cardiovascular Mortality https://www.fightaging.org/archives/2021/11/on-the-ability-of-redundant-blood-vessels-to-lower-cardiovascular-mortality/ A few strategies offer the possibility of growing additional redundant blood vessels, though this is far from rigorously pr...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Neurochem Res. 2021 Nov 20. doi: 10.1007/s11064-021-03488-7. Online ahead of print.ABSTRACTNeurodegenerative disorders are distinguished by the gradual deterioration of the nervous system's structure and function due to oxidative stress, mitochondrial dysfunction, protein misfolding, excitotoxicity, and neuroinflammation. Among these NDs, Alzheimer's disease, Huntington's disease, Parkinson's disease, and amyotrophic lateral sclerosis characterized an increasing dysfunction and loss of neuronal structure leading to neuronal cell death. Although there is currently no drug to totally reverse the effects of NDs, such novel fo...
Source: Neurochemical Research - Category: Neuroscience Authors: Source Type: research
Toxicol Lett. 2021 Nov 17:S0378-4274(21)00883-3. doi: 10.1016/j.toxlet.2021.11.007. Online ahead of print.ABSTRACTImpairment of the astrocytic glutamate transporter excitatory amino acid transporter 2 (EAAT2) is associated with neurological disorders such as Parkinson's disease (PD), Alzheimer's disease (AD), and manganism, a neurological disorder caused by overexposure to manganese (Mn) which shares the features of sporadic PD. Mechanisms of Mn-induced neurotoxicity include dysregulation of EAAT2 following activation of the transcription factor Yin Yang 1 (YY1) by transcriptional upregulation, but the posttranslational me...
Source: Toxicology Letters - Category: Toxicology Authors: Source Type: research
This study hopes to provide reference for mTOR and SCI research and a theoretical basis for SCI biotherapy.PMID:34800780 | DOI:10.1016/j.biopha.2021.112430
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - Category: Drugs & Pharmacology Authors: Source Type: research
Toxicol Lett. 2021 Nov 17:S0378-4274(21)00883-3. doi: 10.1016/j.toxlet.2021.11.007. Online ahead of print.ABSTRACTImpairment of the astrocytic glutamate transporter excitatory amino acid transporter 2 (EAAT2) is associated with neurological disorders such as Parkinson's disease (PD), Alzheimer's disease (AD), and manganism, a neurological disorder caused by overexposure to manganese (Mn) which shares the features of sporadic PD. Mechanisms of Mn-induced neurotoxicity include dysregulation of EAAT2 following activation of the transcription factor Yin Yang 1 (YY1) by transcriptional upregulation, but the posttranslational me...
Source: Toxicology Letters - Category: Toxicology Authors: Source Type: research
Neurochem Res. 2021 Nov 20. doi: 10.1007/s11064-021-03488-7. Online ahead of print.ABSTRACTNeurodegenerative disorders are distinguished by the gradual deterioration of the nervous system's structure and function due to oxidative stress, mitochondrial dysfunction, protein misfolding, excitotoxicity, and neuroinflammation. Among these NDs, Alzheimer's disease, Huntington's disease, Parkinson's disease, and amyotrophic lateral sclerosis characterized an increasing dysfunction and loss of neuronal structure leading to neuronal cell death. Although there is currently no drug to totally reverse the effects of NDs, such novel fo...
Source: Neurochemical Research - Category: Neuroscience Authors: Source Type: research
Bioorg Chem. 2021 Oct 29;118:105457. doi: 10.1016/j.bioorg.2021.105457. Online ahead of print.ABSTRACTSubstitution of hazardous and often harmful organic solvents with "green" and "sustainable" alternative reaction media is always desirous. Ionic liquids (IL) have emerged as valuable and versatile liquids that can replace most organic solvents in a variety of syntheses. However, recently new types of low melting mixtures termed as Deep Eutectic Solvents (DES) have been utilized in organic syntheses. DES are non-volatile in nature, have sufficient thermal stability, and also have the ability to be recycl...
Source: Bioorganic Chemistry - Category: Chemistry Authors: Source Type: research
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