Novel human melanoma brain metastasis models in athymic nude fox1nu mice: Site ‐specific metastasis patterns reflecting their clinical origin

ConclusionsThe present work demonstrates that human brain-metastatic melanoma cells injected intracardially in mice had retained inherent characteristics also in reproducing interaction with subtle microenvironmental brain tissue compartment-specific features. The models offer new possibilities for investigating tumor- and host-associated factors involved in determining tissue specificity of brain metastasis.

Source: Cancer Medicine - October 6, 2021 Category: Cancer & Oncology Authors: Henrik A. Svendsen, Torstein R. Meling, Vigdis Nygaard, Stein Waagene, Hege Russnes, Siri Juell, Siril G. Rogne, Jens Pahnke, Eirik Helseth, Øystein Fodstad, Gunhild M. Mælandsmo Tags: RESEARCH ARTICLE Source Type: research