Collaborative COVID-19 lockdown effort delivers major boost for vaccine innovation in Bristol

Faster vaccine development could be a step closer thanks to £ 4 million investment to Imophoron Ltd, a Bristol University biotech start-up developing a novel, next generation rapid-response vaccine platform called ADDomer ™ . Imophoron will use the investment to bring ADDomer vaccines to clinical stage, initially targeting three viruses, RSV (respiratory syncytial virus), COVID-19, and mosquito-borne Chikungunya.
Source: University of Bristol news - Category: Universities & Medical Training Tags: Announcements, Business and Enterprise, Grants and Awards, Health, International, Research; Faculty of Health Sciences, Faculty of Health Sciences, Bristol Medical School, Faculty of Life Sciences, Faculty of Life Sciences, School of Biochemistry, Faculty Source Type: news

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Conclusion: The current study provided a list of African medicinal plants which demonstrated antiviral activities and could potentially be candidates for COVID-19 treatment. However, all studies were preliminary and in vitro screening. Further in vivo studies are required for plant-based management of viral diseases.
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Dr Ijaz Ali has spent the last 11 years persuading the authorities to use genetically engineered mosquitoes to fight dengue fever. The health department, however, is concerned about unforeseen circumstances that could arise from this method. By Zofeen EbrahimKarachi , Nov 2 2021 (IPS) Twenty-three-year-old Sarah Tajammal felt a sense of “impending doom” as she fought high fever, nausea, bouts of vomiting and extreme fatigue after being diagnosed with dengue two weeks back. Living in Lahore’s DHA area, which has reported the most dengue cases “because of the damp green environment”, she may ha...
Source: IPS Inter Press Service - Health - Category: International Medicine & Public Health Authors: Tags: Asia-Pacific Development & Aid Environment Featured Headlines Health Human Rights Humanitarian Emergencies Inequity TerraViva United Nations Source Type: news
Faster vaccine development could be a step closer thanks to £ 4 million investment to Imophoron Ltd, a Bristol University biotech start-up developing a novel, next generation rapid-response vaccine platform called ADDomer ™ . Imophoron will use the investment to bring ADDomer vaccines to clinical stage, initially targeting three viruses, RSV (respiratory syncytial virus), COVID-19, and mosquito-borne Chikungunya.
Source: University of Bristol news - Category: Universities & Medical Training Tags: Announcements, Business and Enterprise, Grants and Awards, Health, International, Research; Faculty of Health Sciences, Faculty of Health Sciences, Bristol Medical School, Faculty of Life Sciences, Faculty of Life Sciences, School of Biochemistry, Faculty Source Type: news
CONCLUSION: Scrub typhus is an emerging tropical rickettsial disease in the Indian subcontinent. The present study highlights the importance of screening of PUO cases for this important infection as timely institution of simple empirical treatment can prove to be life saving in such positive cases.PMID:34568135 | PMC:PMC8415648 | DOI:10.4103/jfmpc.jfmpc_2392_20
Source: Primary Care - Category: Primary Care Authors: Source Type: research
ConclusionNVK and KSK arms showed a statistically significant reduction in hospital stay time, reduction in viral load of SARS-CoV-2, and time taken for patients to become asymptomatic from symptomatic, when compared to the placebo (decaffeinated tea). The primary outcome measures of the KSK arm were significantly better than those in the NVK arm.
Source: Trials - Category: Research Source Type: clinical trials
The objective of this review is to describe the contributions of research on chikungunya virus infection gained from epidemic in the West Indies and the Guiana Shield.Recent FindingsPrevalence data were similar to those found in the Indian Ocean or Asia during epidemics. Clinically, there is now a better understanding of the typical, atypical, and severe forms. Several studies have insisted on the presence of neurological forms of chikungunya infection, such as encephalitis or Guillain –Barré syndrome. Cases of septic shock due to chikungunya virus as well as thrombotic thrombocytopenic purpura were described ...
Source: Current Tropical Medicine Reports - Category: Tropical Medicine Source Type: research
While most eyes were on COVID-19, researchers have also made groundbreaking advancements in other fields. Here’s a look. The other big vaccine news Public-health officials have long sought a vaccine against malaria, which infects up to 600 million people a year and kills 400,000, mostly children. This year, there was dramatic prog­ress toward that goal. In a study of 450 children in Burkina Faso, published in the Lancet in April, researchers reported that a new malaria vaccine, called R21, is 77% effective—just clearing the World Health Organization’s 75% efficacy standard. However, the sample gro...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized COVID-19 feature Innovation Magazine Source Type: news
Trop Doct. 2021 Jun 7:494755211020899. doi: 10.1177/00494755211020899. Online ahead of print.ABSTRACTAs international travels and destinations increase, travel-related infections increase. It is reported that 6-87% of the travellers contract travel-related infection during or after the trip. Vector-associated pathogens comprise a significant percentage of travel-related infections. Apart from the ubiquitous COVID19, threats such as Dengue, Chikungunya and Zika virus and tick-borne agents have emerged or re-emerged in recent years. The fact that these infections are carried with similar vectors and cause similar symptoms ma...
Source: Tropical Doctor - Category: Tropical Medicine Authors: Source Type: research
Biosens Bioelectron. 2021 May 31;190:113388. doi: 10.1016/j.bios.2021.113388. Online ahead of print.ABSTRACTCo-circulation of coronavirus disease 2019 (COVID-19) and dengue fever has been reported. Accurate and timely multiplex diagnosis is required to prevent future pandemics. Here, we developed an innovative microfluidic chip that enables a snapshot multiplex immunoassay for timely on-site response and offers unprecedented multiplexing capability with an operating procedure similar to that of lateral flow assays. An open microchannel assembly of individually engineered microbeads was developed to construct nine high-dens...
Source: Biosensors and Bioelectronics - Category: Biotechnology Authors: Source Type: research
Purpose of review The COVID-19 pandemic has cast increased attention on emerging infections. Clinicians and public health experts should be aware of emerging infectious causes of encephalitis, mechanisms by which they are transmitted, and clinical manifestations of disease. Recent findings A number of arthropod-borne viral infections -- transmitted chiefly by mosquitoes and ticks -- have emerged in recent years to cause outbreaks of encephalitis. Examples include Powassan virus in North America, Chikungunya virus in Central and South America, and tick-borne encephalitis virus in Europe. Many of these viruses exh...
Source: Current Opinion in Neurology - Category: Neurology Tags: CNS INFLAMMATORY DISORDERS: INFECTIOUS DISEASES: Edited by Erich Schmutzhard Source Type: research
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