Driving Pressure and Normalized Energy Transmission Calculations in Mechanically Ventilated Children Without Lung Disease and Pediatric Acute Respiratory Distress Syndrome*

CONCLUSIONS: Driving pressure is the variable that better discriminates pediatric acute respiratory distress syndrome from nonpediatric acute respiratory distress syndrome in children than the calculations derived from the equation of motion, even when indexed by ideal body weight. Unindexed mechanical power was useless to differentiate against both groups. Future studies should determine the threshold for variables of the energy dissipated by the lungs and their association with clinical outcomes.
Source: Pediatric Critical Care Medicine - Category: Pediatrics Tags: Feature Articles Source Type: research

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Hello all. I am currently applying to residency and all I really know is I really enjoy the ICU. I did back-to-back ICU rotations (Medical, then surgical) for 8 weeks and loved both of my rotations. I am dual applying anesthesia and IM and have equal numbers of interviews in each specialty, but I also have been lucky to receive an invite to IM/Anesthesia combined program. There are aspects to each specialty that I like/dislike. I would like to think that IM/Anesthesia->Anesthesia/ccm... Read more
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Critical Care Source Type: forums
A study of private insurance claims found that the highest markups were in anesthesiology, emergency and critical care, and neurosurgery.Medscape Medical News
Source: Medscape Emergency Medicine Headlines - Category: Emergency Medicine Tags: Family Medicine/Primary Care News Source Type: news
Background Hip fractures are the most frequently occurring serious injury in older people. They are the most common reason for  people over the age of 65 to need emergency anaesthesia and surgery, and account for the most cause of death following an accide...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news
Condition:   Pituitary Neoplasms Interventions:   Drug: Desflurane;   Drug: Propofol Sponsor:   Beijing Tiantan Hospital Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Postoperative Pain;   Weakness, Muscle;   Analgesia;   Motor Activity Interventions:   Procedure: Ultrasound-guided pericapsular nerves group of the hip block;   Procedure: Pericapsular local anesthetic infiltration of the hip Sponsor:   University of Chile Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Introduction: Electrical vagal nerve stimulation is known to decrease gut permeability and alleviate gut injury caused by traumatic hemorrhagic shock. However, the specific mechanism of action remains unclear. Glycocalyx, located on the surface of the intestinal epithelium, is associated with the buildup of the intestinal barrier. Therefore, the goal of our study was to explore whether vagal nerve stimulation affects enterocyte glycocalyx, gut permeability, gut injury, and remote lung injury. Materials and methods: Male Sprague Dawley rats were anesthetized and their cervical nerves were exposed. The rats underw...
Source: Shock - Category: Emergency Medicine Tags: Basic Science Aspects Source Type: research
The objectives of this paper are to compare EIT with an invasive pulse contour analysis (PCA) method in measuring SV during mini-fluid challenge in animals and determine preload responsiveness with EIT. Five pigs were anesthetized and mechanically ventilated. After removing 25% to 30% of the total blood from each animal, multiple fluid injections were conducted. The EIT device successfully tracked changes in SV beat-to-beat during varying volume states, i.e., from hypovolemia and preload responsiveness to target volume and volume overload. From a total of 50 100-mL fluid injections on five pigs (10 injections per pig), the...
Source: Shock - Category: Emergency Medicine Tags: Basic Science Aspects Source Type: research
In conclusion, the kinetics of cardiac and cerebral mitochondrial dysfunction suggests that mitochondrial function does not play a major role in the early phase of the post-resuscitation process but is only involved in the longer pathophysiological events.
Source: Shock - Category: Emergency Medicine Tags: Basic Science Aspects Source Type: research
Discussion: Our results suggest the mediating relationship of acute postoperative pain on PPP may be predicated on select patient and surgical factors.
Source: The Clinical Journal of Pain - Category: Anesthesiology Tags: Original Articles Source Type: research
Eur Cell Mater. 2021 Oct 21;41:334-374. doi: 10.22203/eCM.v042a22.ABSTRACTOsteomyelitis is an inflammatory bone disease caused by an infecting microorganism leading to a gradual bone loss. Due to the difficulty in studying osteomyelitis directly in patients, animal models allow researchers to investigate the pathogenesis of the infection and the development of novel prophylactic, anti-inflammatory and antimicrobial treatment strategies. This review is specifically focused on the in vivo mouse osteomyelitis studies available in literature. Thus, a systematic search on Web of Science and PubMed was conducted using the query ...
Source: European Cells and Materials - Category: Cytology Authors: Source Type: research
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