Evaluation of Host Defense Peptide (CaD23)-Antibiotic Interaction and Mechanism of Action: Insights From Experimental and Molecular Dynamics Simulations Studies

Conclusion: CaD23 is a novel alpha-helical, membrane-active synthetic HDP that can enhance and expedite the antimicrobial action of antibiotics against Gram-positive bacteria when used in combination. MD simulations serves as a powerful tool in revealing the peptide secondary structure, dissecting the mechanism of action, and guiding the design and optimisation of HDPs.
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research

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Euro Surveill. 2021 Nov;26(46). doi: 10.2807/1560-7917.ES.2021.26.46.2002094.ABSTRACTBackgroundInvasive infections caused by Staphylococcus aureus have high clinical and epidemiological relevance. It is therefore important to monitor the S. aureus trends using suitable methods.AimThe study aimed to describe the trends of bloodstream infections (BSI) caused by meticillin-resistant S. aureus (MRSA) and meticillin-susceptible S. aureus (MSSA) in the European Union (EU) and the European Economic Area (EEA).MethodsAnnual data on S. aureus BSI from 2005 to 2018 were obtained from the European Antimicrobial Resistance Surveillanc...
Source: Euro Surveill - Category: Infectious Diseases Authors: Source Type: research
Euro Surveill. 2021 Nov;26(46). doi: 10.2807/1560-7917.ES.2021.26.46.2001537.ABSTRACTBackgroundIntensive care units (ICU) constitute a high-risk setting for antimicrobial resistance (AMR).AimWe aimed to describe secular AMR trends including meticillin-resistant Staphylococcus aureus (MRSA), glycopeptide-resistant enterococci (GRE), extended-spectrum cephalosporin-resistant Escherichia coli (ESCR-EC) and Klebsiella pneumoniae (ESCR-KP), carbapenem-resistant Enterobacterales (CRE) and Pseudomonas aeruginosa (CRPA) from Swiss ICU. We assessed time trends of antibiotic consumption and identified factors associated with CRE and...
Source: Euro Surveill - Category: Infectious Diseases Authors: Source Type: research
Euro Surveill. 2021 Nov;26(46). doi: 10.2807/1560-7917.ES.2021.26.46.2002094.ABSTRACTBackgroundInvasive infections caused by Staphylococcus aureus have high clinical and epidemiological relevance. It is therefore important to monitor the S. aureus trends using suitable methods.AimThe study aimed to describe the trends of bloodstream infections (BSI) caused by meticillin-resistant S. aureus (MRSA) and meticillin-susceptible S. aureus (MSSA) in the European Union (EU) and the European Economic Area (EEA).MethodsAnnual data on S. aureus BSI from 2005 to 2018 were obtained from the European Antimicrobial Resistance Surveillanc...
Source: Euro Surveill - Category: Infectious Diseases Authors: Source Type: research
Euro Surveill. 2021 Nov;26(46). doi: 10.2807/1560-7917.ES.2021.26.46.2001537.ABSTRACTBackgroundIntensive care units (ICU) constitute a high-risk setting for antimicrobial resistance (AMR).AimWe aimed to describe secular AMR trends including meticillin-resistant Staphylococcus aureus (MRSA), glycopeptide-resistant enterococci (GRE), extended-spectrum cephalosporin-resistant Escherichia coli (ESCR-EC) and Klebsiella pneumoniae (ESCR-KP), carbapenem-resistant Enterobacterales (CRE) and Pseudomonas aeruginosa (CRPA) from Swiss ICU. We assessed time trends of antibiotic consumption and identified factors associated with CRE and...
Source: Euro Surveill - Category: Infectious Diseases Authors: Source Type: research
Euro Surveill. 2021 Nov;26(46). doi: 10.2807/1560-7917.ES.2021.26.46.2002094.ABSTRACTBackgroundInvasive infections caused by Staphylococcus aureus have high clinical and epidemiological relevance. It is therefore important to monitor the S. aureus trends using suitable methods.AimThe study aimed to describe the trends of bloodstream infections (BSI) caused by meticillin-resistant S. aureus (MRSA) and meticillin-susceptible S. aureus (MSSA) in the European Union (EU) and the European Economic Area (EEA).MethodsAnnual data on S. aureus BSI from 2005 to 2018 were obtained from the European Antimicrobial Resistance Surveillanc...
Source: Euro Surveill - Category: Infectious Diseases Authors: Source Type: research
Euro Surveill. 2021 Nov;26(46). doi: 10.2807/1560-7917.ES.2021.26.46.2001537.ABSTRACTBackgroundIntensive care units (ICU) constitute a high-risk setting for antimicrobial resistance (AMR).AimWe aimed to describe secular AMR trends including meticillin-resistant Staphylococcus aureus (MRSA), glycopeptide-resistant enterococci (GRE), extended-spectrum cephalosporin-resistant Escherichia coli (ESCR-EC) and Klebsiella pneumoniae (ESCR-KP), carbapenem-resistant Enterobacterales (CRE) and Pseudomonas aeruginosa (CRPA) from Swiss ICU. We assessed time trends of antibiotic consumption and identified factors associated with CRE and...
Source: Euro Surveill - Category: Infectious Diseases Authors: Source Type: research
Euro Surveill. 2021 Nov;26(46). doi: 10.2807/1560-7917.ES.2021.26.46.2002094.ABSTRACTBackgroundInvasive infections caused by Staphylococcus aureus have high clinical and epidemiological relevance. It is therefore important to monitor the S. aureus trends using suitable methods.AimThe study aimed to describe the trends of bloodstream infections (BSI) caused by meticillin-resistant S. aureus (MRSA) and meticillin-susceptible S. aureus (MSSA) in the European Union (EU) and the European Economic Area (EEA).MethodsAnnual data on S. aureus BSI from 2005 to 2018 were obtained from the European Antimicrobial Resistance Surveillanc...
Source: Euro Surveill - Category: Infectious Diseases Authors: Source Type: research
Euro Surveill. 2021 Nov;26(46). doi: 10.2807/1560-7917.ES.2021.26.46.2001537.ABSTRACTBackgroundIntensive care units (ICU) constitute a high-risk setting for antimicrobial resistance (AMR).AimWe aimed to describe secular AMR trends including meticillin-resistant Staphylococcus aureus (MRSA), glycopeptide-resistant enterococci (GRE), extended-spectrum cephalosporin-resistant Escherichia coli (ESCR-EC) and Klebsiella pneumoniae (ESCR-KP), carbapenem-resistant Enterobacterales (CRE) and Pseudomonas aeruginosa (CRPA) from Swiss ICU. We assessed time trends of antibiotic consumption and identified factors associated with CRE and...
Source: Euro Surveill - Category: Infectious Diseases Authors: Source Type: research
BackgroundInvasive infections caused byStaphylococcus aureus have high clinical and epidemiological relevance. It is therefore important to monitor theS. aureus trends using suitable methods.AimThe study aimed to describe the trends of bloodstream infections (BSI) caused by meticillin-resistantS. aureus (MRSA) and meticillin-susceptibleS. aureus (MSSA) in the European Union (EU) and the European Economic Area (EEA).MethodsAnnual data onS. aureus BSI from 2005 to 2018 were obtained from the European Antimicrobial Resistance Surveillance Network (EARS-Net). Trends of BSI were assessed at the EU/EEA level by adjusting for blo...
Source: Eurosurveillance - Category: Infectious Diseases Authors: Source Type: research
ConclusionsOur results suggest that the ongoing replacement of ST239 by ST59 in China is not associated to higher AMR carriage or biofilm production. However, the increase in ST59 prevalence is concerning since it is linked to a higher potential for virulence, aided by the carriage of thechp gene.
Source: Genome Medicine - Category: Genetics & Stem Cells Source Type: research
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