A molecular classification of moles and its use in filiation tests

J Forensic Sci. 2021 Oct 1. doi: 10.1111/1556-4029.14890. Online ahead of print.ABSTRACTPregnancies, including ones that follow sexual assaults, occasionally produce hydatidiform moles. The alleged fathers (AFs) of moles have been tested for paternity by identifying the mole's locus phenotype-the one or two visible paternal obligate alleles (POAs) per locus. The probability that the mole inherited the POAs from the AF was divided by the probability that the mole inherited the POAs from a random man. This likelihood ratio (LR) would increase if the mole's specific genotype was known. Moles are generated in five different ways that produce five distinct genotypes. Examining a mole's multilocus STR profile reveals a mole's pathogenesis, determines locus genotypes, and increases paternity LRs.PMID:34596233 | DOI:10.1111/1556-4029.14890
Source: Journal of Forensic Sciences - Category: Forensic Medicine Authors: Source Type: research