Hemolytic Uremic Syndrome is associated with dysregulation of Chemokine Receptor expression in Circulating Monocytes.

Conclusions: The increase in CCRs expression correlates with HUS severity suggesting that the dysregulation of these receptors might contributes to an increased risk for renal damage. Activated Mo could be recruited by chemokines and then receptors could be dysregulated. The dysregulation of CCRs and their ligands observed during acute period suggest that chemokine pathway would participate in HUS development.

Source: Clinical Science - March 6, 2015 Category: Biomedical Science Authors: M Ramos, M Ruggieri, A Cecilia Panek, M Pilar Mejias, R Jimena Fernandez-brando, M Jimena Abrey-Recalde, A Exeni, C Barilari, R Exeni, M Sandra Palermo Source Type: research