Weaker protection against tuberculosis in BCG-vaccinated male 129 S2 mice compared to females

In conclusion, we found sex-specific differences in response to M. tuberculosis H37Rv -challenge in BCG-vaccinated 129 S2 mice. This highlights the need to include both male and female mice in preclinical testing of vaccine candidates.PMID:34602301 | DOI:10.1016/j.vaccine.2021.09.039

Source: Vaccine - October 4, 2021 Category: Allergy & Immunology Authors: Natalie E Nieuwenhuizen Joanna Zyla Ulrike Zedler Silke Bandermann Ulrike Abu Abed Volker Brinkmann Stefan H E Kaufmann Source Type: research