The invasive pathogen < i > Yersinia pestis < /i > disrupts host blood vasculature to spread and provoke hemorrhages

In this study, an innovative model ofin vivo infection was used to focus on the interaction betweenY.pestis and its host vascular system. In the draining lymph nodes and in secondary organs, bacteria provoked the porosity and disruption of blood vessels. Anin vitro model of endothelial barrier showed a role in this phenotype for the pYV/pCD1 plasmid that carries a Type Three Secretion System. This work supports that the pYV/pCD1 plasmid is responsible for the powerful tissue invasiveness capacity of the plague bacillus and the hemorrhagic features of plague.
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research