Histopathologic and Urodynamic Effects of the Anticholinergic Drugs Oxybutynin, Tolterodine, and Trospium on the Bladder

ConclusionIntravesical oxybutynin treatment was observed to be safe; however, a single daily dose of oxybutynin may not be sufficient to increase bladder capacity. Intravesical use of trospium and tolterodine at high doses caused epithelial destruction and diffuse inflammation in the bladder mucosa. The irritation associated with epithelial destruction and inflammation prevented an increase in bladder capacity.

Source: LUTS: Lower Urinary Tract Symptoms - January 1, 2015 Category: Urology & Nephrology Authors: Seyfettin ORGEN, Hasan DELIKTAS, Hayrettin SAHIN, Abdullah GEDIK, Yusuf NERGIS Tags: ORIGINAL ARTICLE Source Type: research