Higher detection of JC polyomavirus in colorectal cancerous tissue after pretreatment with topoisomerase I enzyme; colorectal tissue serves as a JCPyV persistence site

CONCLUSIONS: The presence of JCPyV in CRC tissues, as well as T-Ag localization in the nucleolus, where its oncogenic effect takes place, may provide supporting evidence for JCPyV involvement in CRC development. The study highlights the importance of using topoisomerase I to enhance JCPyV genome detection. Also, colorectal tissue is one of the permissive human tissue for JC resistance after preliminary infection.PMID:34592199 | DOI:10.1016/j.yexmp.2021.104687

Source: Experimental and Molecular Pathology - September 30, 2021 Category: Pathology Authors: Samira Izi Masoud Youssefi Nema Mohammadian Roshan Amir Azimian Saeid Amel Jamehdar Farnaz Zahedi Avval Source Type: research