Validation of Pediatric Patient Reported Outcomes in Chronic Diseases (PEPR) Consortium (U19)

Funding Opportunity RFA-AR-15-014 from the NIH Guide for Grants and Contracts. The purpose of this FOA is to solicit applications for the Validation of Pediatric Patient Reported Outcomes in Chronic Diseases (PEPR) Consortium. The NIAMS, on behalf of the National Institutes of Health, intends to capitalize on recent advances in the science of Patient Reported Outcomes (PROs) to measure the patient experience in clinical care and research in children with a variety of chronic diseases and conditions (e.g., asthma, juvenile arthritis, cystic fibrosis, diabetes, obesity and overweight, chronic kidney disease, inflammatory bowel disease, sickle cell disease, malnutrition, developmental disabilities including attention deficit/hyperactivity disorder and autism spectrum disorder, cerebral palsy and mental illnesses) using the Patient-Reported Outcomes Measurement Information System (PROMIS) tools and approaches coupled with detailed clinical phenotyping and/or biospecimen collection in well-characterized human cohorts. The Patient Reported Outcomes Measurement Information System (PROMIS) is a system of highly reliable, precise measures of patientreported health status for physical, mental, and social wellbeing. PROMIS tools measure what patients are able to do and how they feel by asking questions. PROMIS measures can be used as primary or secondary endpoints in clinical studies of the effectiveness of treatment.
Source: NIH Funding Opportunities (Notices, PA, RFA) - Category: Research Source Type: funding

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In this study, serum IL6 was measured by ELISA, and the HSD11B1rs12086634(T/G) polymorphism was analyzed using a TaqMan allelic discrimination assay technique. There were statistically significant differences between the two studied groups concerning the serum IL-6 level and HSD11B1rs12086634(T/G) genotype distribution, with increased serum IL6 and increased frequencies of the GG and TG genotypes in patients with PCO. The GG genotype of HSD11B1 rs12086634(T/G) and its associated high level of serum IL-6 may represent genetic risk factors for PCOS.
Source: Meta Gene - Category: Genetics & Stem Cells Source Type: research
ConclusionThe CFQL-2 is a brief, reliable scale that effectively measures psychosocial aspects of QoL and is sensitive to changes in QoL in families of children with ASD or related neurodevelopmental disorders. Child externalizing behavior is strongly associated with reductions in multiple aspects of child and family psychosocial QoL.
Source: Research in Autism Spectrum Disorders - Category: Psychiatry Source Type: research
ConclusionThis meta-analysis suggested a significant association between MTHFR gene polymorphism (C677T and A1298C) and ASD risk.
Source: Research in Autism Spectrum Disorders - Category: Psychiatry Source Type: research
ConclusionThe findings from this study have established the need to improve current education and rehabilitation programmes for patients with CHF by addressing those factors significantly influencing their adherence to diet and medication.
Source: Heart and Lung: The Journal of Acute and Critical Care - Category: Respiratory Medicine Source Type: research
Publication date: Available online 16 November 2019Source: Social Science &MedicineAuthor(s): Henry J. Whittle, Anna M. Leddy, Jacqueline Shieh, Phyllis C. Tien, Ighovwerha Ofotokun, Adaora A. Adimora, Janet M. Turan, Edward A. Frongillo, Bulent Turan, Sheri D. WeiserAbstractMaterial-need insecurities (including insecurities in basic resources such as income, food, housing, and healthcare) are widespread in the United States (US) and may be important predictors of poor health outcomes. How material-need insecurities besides food insecurity are experienced, however, remains under-researched, including how multiple mater...
Source: Social Science and Medicine - Category: Psychiatry & Psychology Source Type: research
Publication date: Available online 16 November 2019Source: Trends in Endocrinology &MetabolismAuthor(s): Carina Bodden, Anthony J. Hannan, Amy C. ReicheltGlobally, obesity has reached epidemic proportions. The rapidly increasing numbers of overweight people can be traced back to overconsumption of energy-dense, poor-quality foods as well as physical inactivity. This development has far-reaching and costly implications. Not only is obesity associated with serious physiological and psychological complications, but mounting evidence also indicates a ripple effect through generations via epigenetic changes. Parental obesit...
Source: Trends in Endocrinology and Metabolism - Category: Endocrinology Source Type: research
DiscussionHyperchloremic acidosis is associated with a non-anion gap, decrease in plasma bicarbonate and increase in plasma chloride. Rarely, as with this case, it may present with a high-anion gap. The use of bicarbonate therapy has shown improvement in cases of non-anion gap acidosis however there is very little data to support its role in high-anion gap hyperchloremic metabolic acidosis.
Source: African Journal of Emergency Medicine - Category: Emergency Medicine Source Type: research
Publication date: Available online 17 November 2019Source: Pharmacological ResearchAuthor(s): Moein Askarpour, Amir Hadi, Maryam Miraghajani, Michael Symonds, Ali Sheikhi, Ehsan GhaediAbstractDespite preclinical studies demonstrating the efficacy of L-carnitine supplementation for weight management, findings in clinical setting are contradictory. Electronic bibliographical databases were systematically searched up to February 2019 with no limitation in language, including Scopus, PubMed, ISI Web of Science and Cochrane Library. Clinical trials registry platform were also searched. All randomized controlled trials (RCTs) wh...
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
This study aimed to investigate the mechanism of action of ginger extract and its compound, 6-shogaol, on pancreatic islets as well as on expressions of TRPV-1 and NMDAR2B in the spinal cord of streptozotocin (STZ)-induced mice model of PDN.Materials and methodsSixty-four 5–6 months old male-Balb/C mice were induced with 110 mg/kgBW STZ i.p., while eight mice were used as control group. Mice with blood glucose level ≥200 mg/d, that suffered hyperalgesia and allodynia were classified as PDN mice. Hot plate and von Frey filament tests were performed once a week until termination. At day 28 after considered as PDN,...
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
ConclusionsThe PCV-VG mode of ventilation limited the peak inspiratory pressure, decreased the driving pressure and increased the dynamic compliance compared to VCV in obese patients undergoing laparoscopic hysterectomy. PCV-VG may be a preferable modality to prevent barotrauma during laparoscopic surgeries in obese patients.ResumoJustificativa e objetivosO objetivo deste estudo foi investigar a eficácia dos modos de ventilação garantida por volume controlado por pressão (PCV-VG) e ventilação controlada por volume (VCV) para manter pressões adequadas nas vias aéreas, ...
Source: Brazilian Journal of Anesthesiology - Category: Anesthesiology Source Type: research
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