Hypothesis on the possible relevance of the immunogenic cell death in the treatment of gestational trophoblastic neoplasms

Transl Oncol. 2021 Sep 27;14(12):101224. doi: 10.1016/j.tranon.2021.101224. Online ahead of print.ABSTRACTThe genetic background and the antigenic landscape of cancer cells play a critical role in the response to immunotherapies. A high tumor antigenicity, together with an increased adjuvanticity potentially induced by a peculiar type of cell death, namely immunogenic cell death (ICD), could foster the response to immunogenic therapies. The gestational trophoblastic neoplasm (GTN) is a one-of-a-kind cancer in the oncological landscape due to its exclusive genomic makeup. The prognosis of GTN is significantly better than non-gestational trophoblastic neoplasm (nGTN). Due to its peculiar genetic inheritance, GTN potentially constitutes a singular archetype in the immuno-oncological field.PMID:34592590 | DOI:10.1016/j.tranon.2021.101224
Source: Translational Oncology - Category: Cancer & Oncology Authors: Source Type: research