IJERPH, Vol. 18, Pages 10388: CoCoss-Trial: Concurrent Comparison of Self-Sampling Devices for HPV-Detection

IJERPH, Vol. 18, Pages 10388: CoCoss-Trial: Concurrent Comparison of Self-Sampling Devices for HPV-Detection International Journal of Environmental Research and Public Health doi: 10.3390/ijerph181910388 Authors: Faruk Cem Ertik Johanna Kampers Fabienne Hülse Claudia Stolte Gerd Böhmer Peter Hillemanns Matthias Jentschke High-risk human papillomavirus (hr-HPV) infection of the cervicovaginal tract is known to be the major cause of cervical cancer. Similar to various other countries, Germany introduced an organized combined screening including cytology and HPV testing in 2020. The participation rate was around 70% in the past. Self-testing for hr-HPV infections could be an option to increase the participation rate. Two dry vaginal self-sampling devices and a device for the self-collection of first-void urine were evaluated in combination with a PCR-based hr-HPV test regarding their clinical performance (sensitivity for high-grade cervical intraepithelial neoplasia, CIN 2+). A cervical smear taken by a clinician during colposcopy was used as reference. This open prospective multicenter trial recruited patients referred to the two participating colposcopy clinics (Hannover Medical School and IZD Hannover, Germany) with abnormal results from cervical cancer screening from 05/2020 to 11/2020. All patients received three CE-certified self-sampling devices (FLOQSwabs, COPAN, Italy; Evalyn Brush, Rovers Medical Devices, the Netherlands; Colli-Pee FV-5000, Novosa...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research