Pregnancy Complications Higher in Women With Schizophrenia

Women with schizophrenia also experience higher rates of delivery complications and neonatal complications versus women without mental disorders
Source: The Doctors Lounge - Psychiatry - Category: Psychiatry Tags: Family Medicine, Gynecology, Psychiatry, Journal, Source Type: news

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Neuropharmacology. 2021 Oct 16;201:108841. doi: 10.1016/j.neuropharm.2021.108841. Online ahead of print.ABSTRACTA strong association between perinatal viral infections and neurodevelopmental disorders has been established. Both the direct contact of the virus with the developing brain and the strong maternal immune response originated by viral infections can impair proper neurodevelopment. Coronavirus disease 2019 (COVID-19), caused by the highly-infectious severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is currently responsible for a large global outbreak and is a major public health issue. While initial stu...
Source: Neuropharmacology - Category: Drugs & Pharmacology Authors: Source Type: research
Contributors : Roberto Capell án ; Alejandro Higuera-MatasSeries Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicusSubstance use disorders are more prevalent in schizophrenia, worsening its course and prognosis. Here, we used a double-hit rat model, combining maternal immune activation (MIA) and peripubertal stress (PUS), to study cocaine addiction and the underlying neurobehavioral alterations. We injected lipopolysaccharide (LPS) or saline on gestational days 15 and 16 to pregnant rats. Their male offspring were then subjected to unpredictable stress during adolescence. When rats...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Rattus norvegicus Source Type: research
Hypofunction of glutamatergic signaling is causally linked to neurodevelopmental disorders, including psychotic disorders like schizophrenia and bipolar disorder. Kynurenic acid (KYNA) has been found to be elevated in postmortem brain tissue and cerebrospinal fluid of patients with psychotic illnesses and may be involved in the hypoglutamatergia and cognitive dysfunction experienced by these patients. As insults during the prenatal period are hypothesized to be linked to the pathophysiology of psychotic disorders, we presently utilized the embryonic kynurenine (EKyn) paradigm to induce a prenatal hit. Pregnant Wistar dams ...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
CONCLUSION: These findings support the idea of using anti-inflammatory agents as adjunctive therapy in patients with SCZ.PMID:34530042 | DOI:10.1016/j.bbr.2021.113581
Source: Behavioural Brain Research - Category: Neurology Authors: Source Type: research
TITUSVILLE, N.J., Sept. 1, 2021 – The Janssen Pharmaceutical Companies of Johnson &Johnson today announced the U.S. Food and Drug Administration (FDA) has approved long-acting atypical antipsychotic INVEGA HAFYERA™ (6-month paliperidone palmitate), the first-and-only twice-yearly injectable for the treatment of schizophrenia in adults. Before transitioning to INVEGA HAFYERA™, patients must be adequately treated with INVEGA SUSTENNA® (1-month paliperidone palmitate) for at least four months, or INVEGA TRINZA® (3-month paliperidone palmitate) for at least one 3-month injection cycle.1 The FDA ap...
Source: Johnson and Johnson - Category: Pharmaceuticals Tags: Innovation Source Type: news
Prim Care Companion CNS Disord. 2021 Aug 19;23(4):20l02854. doi: 10.4088/PCC.20l02854.NO ABSTRACTPMID:34416102 | DOI:10.4088/PCC.20l02854
Source: The Primary Care Companion for CNS Disorders - Category: Primary Care Authors: Source Type: research
Psychiatr Pol. 2021 Apr 30;55(2):261-274. doi: 10.12740/PP/132953. Epub 2021 Apr 30.ABSTRACTIn 2021, one-hundred and ten years passed since a Swiss psychiatrist, Eugen Bleuler, introduced a term ‛schizophrenia',denoting one of the most severe and stigmatizing psychiatric illnesses. Presently, it is known that the etiopathogenesis of schizophrenia is multifactorial, and a neurodevelopmental theory has been the most important pathogenic concept for more than 30 years. The theory postulates an interaction between genetic predisposition and environmental factors. In recent years, mainly thanks to employing the genome-wide as...
Source: Psychiatria Polska - Category: Psychiatry Authors: Source Type: research
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