CSF Levels of CXCL12 and Osteopontin as Early Markers of Primary Progressive Multiple Sclerosis

Conclusions At the time of diagnosis, a specific CSF protein profile can recognize the presence of early intrathecal inflammatory processes, possibly stratifying PPMS with respect to RRMS. Elevated CSF levels of CXCL12 and osteopontin suggested a key role of brain innate immunity and glia activity in MS. These molecules could represent useful candidate markers of MS progression, with implications for the pathogenesis and treatment of progressive MS. Classification of Evidence This study provides Class III evidence that CXCL12 and monocyte-related osteopontin may be correlated with PPMS, and IL-10 may be related to RRMS. It is may be correlated due to Bonferroni correction negating the statistical correlations found in the study.

http://nn.neurology.org/cgi/content/short/8/6/e1083?rss=1

Source: Neurology Neuroimmunology and Neuroinflammation - September 29, 2021 Category: Neurology Authors: Marastoni, D., Magliozzi, R., Bolzan, A., Pisani, A. I., Rossi, S., Crescenzo, F., Montemezzi, S., Pizzini, F. B., Calabrese, M. Tags: Multiple sclerosis Article Source Type: research