Salvia officinalis Extract and 17 β-Estradiol Suppresses Ovariectomy Induced Osteoporosis in Female Rats

Conclusion:</b> These results suggest that both SOE and E<sub>2</sub> or their combined administration are efficient inhibitors against ovariectomy-induced bone loss in female rats.PMID:34486329 | DOI:10.3923/pjbs.2021.434.444
Source: Pakistan Journal of Biological Sciences: PJBS - Category: Biomedical Science Authors: Source Type: research

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Conditions:   Bullosa Epidermolysis;   Vitamin D Deficiency;   Osteoporosis;   Osteopenia;   Phosphorus and Calcium Disorders Interventions:   Drug: Vitamin D;   Dietary Supplement: Oral nutrional supplement;   Combination Product: Vitamin D+Oral nutrional supplement Sponsor:   National Medical Research Center for Children's Health, Russian Federation Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Background: Chronic obstructive pulmonary disease (COPD) is a systemic disease associated to various comorbidities. Osteoporosis, Vitamine D deficiency and denutrition are common in these patients.Aim: Investigate association between bone mineral density, body composition and bone turnover markers in Tunisian patients with COPD and its correlation with the severity of the disease.Methods: Prospective study conducted in a tertiary care hospital in Tunis. Patients with stable COPD were included. Total hip, lumbar spine, and whole-body T-score were measured with dual-energy X-ray absorptiometry (BMD). Osteoporosis was defined as T-score
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Monitoring airway disease Source Type: research
ABSTRACTVitamin D deficiency, persistent hyperparathyroidism, and bone loss are common after kidney transplantation (KTx). However, limited evidence exists regarding the effects of cholecalciferol supplementation on parathyroid hormone (PTH) and bone loss after KTx. In this prespecified secondary endpoint analysis of a randomized controlled trial, we evaluated changes in PTH, bone metabolic markers, and bone mineral density (BMD). At 1-month post-transplant, we randomized 193 patients to an 11-month intervention with cholecalciferol (4000  IU/day) or placebo. The median baseline 25-hydroxyvitamin D (25[OH]D) level w...
Source: Journal of Bone and Mineral Research - Category: Orthopaedics Authors: Tags: Clinical Trial Source Type: research
Z Gastroenterol. 2021 Oct 28. doi: 10.1055/a-1482-9236. Online ahead of print.ABSTRACTBACKGROUND: Non-alcoholic fatty liver disease (NAFLD) and osteoporosis are common diseases with a rising incidence worldwide. Both diseases occur in similar patient populations, however, data on their mutual influence are conflicting. Here, we aimed to evaluate the impact of NAFLD on the incidence of osteoporosis and fractures by using the Disease Analyzer database featuring data on diagnoses, prescriptions, and demographic aspects of 7.49 million cases followed in general practices in Germany.METHODS: A total of 50,689 patients with NAFL...
Source: Zeitschrift fur Gastroenterologie - Category: Gastroenterology Authors: Source Type: research
Conclusion: There is only weak evidence to support the relationship between BPPV and osteoporosis or low serum 25-hydroxyvitamin D levels. Further prospective studies with more robust methodologies are needed to clarify the association between BPPV and disorders of bone metabolism.
Source: Ear and Hearing - Category: Audiology Tags: Systematic Review Source Type: research
CONCLUSIONS: The 25(OH)D level in vivo was negatively correlated with the acute phase adverse reactions after the first infusion of zoledronic acid. When the rate of bone formation is increased and osteoblasts are active, the risk of acute phase adverse reactions is increased with the use of zoledronic acid as antiosteoporosis therapy. There was no significant correlation between 25(OH)D levels and musculoskeletal symptoms after teriparatide acetate treatment of osteoporosis. When the rate of bone formation is increased and osteoblasts are active, the risk of adverse reactions to musculoskeletal symptoms is increased with ...
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Authors: Source Type: research
This study determined the prevalence of a blunted PTH response to vitamin D deficiency among apparently healthy young Saudi women and assessed anthropometric and biochemical factors associated with this response by performing a secondary analysis of data obtained from a cross-sectional study conducted at the "Center of Excellence for Osteoporosis research." Overall, 315 women (aged 20-45 years) with vitamin D deficiency (serum 25-hydroxyvitamin D (25(OH)D) levels
Source: International Journal of Endocrinology - Category: Endocrinology Authors: Source Type: research
AbstractSummaryVitamin D intake over the recommended dose is usually associated with high serum 25(OH)D levels and generally not associated with symptoms of hypercalcemia. High doses of cholecalciferol need to be avoided to protect against vitamin D toxicity and related complications. Strict adherence to the clinical guidelines for treating vitamin D deficiency can ensure safe and effective treatment.PurposeWe observed a tendency to use high doses of cholecalciferol for vitamin D deficiency treatment or vitamin D supplementation. We aimed to determine the biochemical characteristics of patients with high normal and elevate...
Source: Archives of Osteoporosis - Category: Orthopaedics Source Type: research
Conclusion:</b> These results suggest that both SOE and E<sub>2</sub> or their combined administration are efficient inhibitors against ovariectomy-induced bone loss in female rats.PMID:34486329 | DOI:10.3923/pjbs.2021.434.444
Source: Pakistan Journal of Biological Sciences: PJBS - Category: Biomedical Science Authors: Source Type: research
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