Crohn's disease: Five symptoms that could prove life-threatening if not treated early
CROHN'S disease is a chronic condition where parts of the digestive system become inflamed. Though various studies have looked into the causes of Crohn's disease, the actual cause is unknown. However, scientists do know that it is one type of a condition known as inflammatory bowel disease . If Crohn's disease is not diagnosed, fatal complications can result. In rare cases, these complications can be fatal.
aczmarek Andrzej Radzikowski Jarosław Walkowiak The human leukocyte antigen (HLA) allele group HLA-DQA1*05 predisposes to ulcerative colitis (UC) and is associated with the development of antibodies against infliximab in patients with inflammatory bowel disease (IBD). Therefore, we hypothesized that the presence of HLA-DQA1*05 correlates with characteristics of pediatric IBD. Within a multi-center cohort in Poland, the phenotype at diagnosis and worst flare was established and HLA-DQA1*05 status was assessed enabling genotype-phenotype analyses. HLA-DQA1*05 was present in 221 (55.1%) out of 401 children with IBD (...
CONCLUSION: HPM improves CD-associated intestinal fibrosis by suppressing the RhoA/ROCK1/MLC pathway.PMID:34840583 | PMC:PMC8612780 | DOI:10.1155/2021/2247953
CONCLUSIONS: The current study showed BAE is a very useful modality for detecting MD compared with other conventional modalities.PMID:34840565 | PMC:PMC8616713 | DOI:10.1155/2021/9574737
This article discusses early diagnosis, disease severity and classification, familial predisposition and genomics, and clinical management in the primary care setting.
AbstractBackgroundInter-alpha-trypsin inhibitor heavy chain 4 (ITIH4) plays vital roles in inflammatory and auto-immune diseases, but its correlations with disease risk and clinical features in inflammatory bowel disease (IBD) need further investigation. The present study intended to explore the correlation of ITIH4 with disease activity and inflammation, as well as its change after treatment in IBD patients.MethodsTotally, 40 active Crohn ’s disease (A-CD) patients, 40 clinical-remission CD (R-CD) patients, 40 active ulcerative colitis (A-UC) patients, 40 clinical-remission UC (R-UC) patients, and 40 health controls...
CROHN'S disease is the painful digestive condition with unusual warning signs. The colour of your poo being one of them. What to look out for?
In this study, we described a unique case of cutaneous metaplasia on the elbow of a 25-year-old man who had a clinical history of epidermolysis bullosa simplex, but had no history of any gastrointestinal disease. The lesion had been clinically stable for 5 years. Histopathologically, the epithelium showed many columnar cells with mucinous cytoplasm, with no atypia or mitoses. The proliferation rate was low (7% by Ki67). The metaplastic areas expressed epithelial membrane antigen, carcinoembryonic antigen, cytokeratin 7, MUC5AC, MUC2, and Cyclin-D1.
Locum - Physician - Gastroenterologist Pittsfield, MA This will be an ongoing assignment Patient Volume: 5-10 consults per day, 5-10 procedures per day (during the week). A few patients and occasional procedures on weekends. Travel/lodging is reimbursable We provide treatment for all digestive diseases and conditions including: • Digestive tract bleeding • Celiac disease • Colitis • Colon polyps • Crohns • Incontinence • Gallstones • Hemochromatosis • Hepatitis • Irritable Bowel... Read more
Crohn's disease (CD) patients included in the TAILORIX trial started infliximab in combination with an immunosuppressant for one year. The aim of the present study was to determine the long-term disease course beyond the study period.
CONCLUSION: The rate of MEFV gene mutations was high in patients with UC who required surgery. These patients have frequent and severe attacks, indicating that the mutations are related to disease severity. MEFV mutation as a modifier factor of IBD should be considered.PMID:34819953 | PMC:PMC8608532 | DOI:10.1155/2021/5538150