Benefit of 5ASA Use After Anti-TNF or Immunomodulator in IBD Benefit of 5ASA Use After Anti-TNF or Immunomodulator in IBD

5ASA is still used as first-line therapy in the treatment of mild to moderate ulcerative colitis. Is there a benefit to continuing it once biological or immunomodulator therapy is initiated?Alimentary Pharmacology &Therapeutics
Source: Medscape General Surgery Headlines - Category: Surgery Tags: Gastroenterology Journal Article Source Type: news

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CONCLUSION: The rate of MEFV gene mutations was high in patients with UC who required surgery. These patients have frequent and severe attacks, indicating that the mutations are related to disease severity. MEFV mutation as a modifier factor of IBD should be considered.PMID:34819953 | PMC:PMC8608532 | DOI:10.1155/2021/5538150
Source: Gastroenterology Research and Practice - Category: Gastroenterology Authors: Source Type: research
Inflammatory bowel disease (IBD), including Crohn’s disease and ulcerative colitis, are chronic, relapsing intestinal inflammatory disorders. Although the molecular mechanisms governing the pathogenesis of IBD are not completely clear, the main factors are presumed to be a complex interaction between genetic predisposition, host immune response and environmental exposure, especially the intestinal microbiome. Currently, most studies have focused on the role of gut bacteria in the onset and development of IBD, whereas little attention has been paid to the enteroviruses. Among of them, viruses that infect prokaryotes, ...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
Conclusion: Cerebral venous thrombosis associated with covid-19 is a rare complication that usually occurs in young adults. It may touch patients with no medical history and with a mild covid-19 infection.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Clinical problems Source Type: research
Australas J Dermatol. 2021 Nov 24. doi: 10.1111/ajd.13754. Online ahead of print.NO ABSTRACTPMID:34817061 | DOI:10.1111/ajd.13754
Source: The Australasian Journal of Dermatology - Category: Dermatology Authors: Source Type: research
Arch Iran Med. 2021 Sep 1;24(9):665-669. doi: 10.34172/aim.2021.95.ABSTRACTBACKGROUND: Colectomy is considered as a part of therapeutic armamentarium in ulcerative colitis. The availability of new biologic treatments might have affected the trend of using this modality.METHODS: The hospital records of all tertiary centers in Shiraz, which are the main centers for the treatment of ulcerative colitis (UC) in southern Iran, were reviewed to estimate the total number of admissions for the treatment of severe UC and colectomy among patients from 2009 to 2019. In this historical cohort study, information about the current status...
Source: Archives of Iranian Medicine - Category: Middle East Health Authors: Source Type: research
No abstract available
Source: Journal of Pediatric Gastroenterology and Nutrition - Category: Gastroenterology Tags: Invited Commentary Source Type: research
Conclusions: This is the first study to describe pediatric and parent experiences receiving FMT. This information is valuable to develop and encourage future FMT trials involving children. Pre-treatment, concerns about FMT were common. Post-treatment, patients reported tolerance to FMT and a desire to continue receiving this therapy if available. Further trials of FMT in UC are needed. Investigators should include pediatric patients without concern of acceptance.
Source: Journal of Pediatric Gastroenterology and Nutrition - Category: Gastroenterology Tags: Original Articles: Gastroenterology Source Type: research
In conclusion, this study shows that the application of engineered S. cerevisiae attenuated DSS-induced colitis in mice via suppressing macrophage pyroptosis and modulating the intestinal microbiota, which is an effective and safe treatment strategy for ulcerative colitis.
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Conclusions: Hemostasis is a conspicuous effect of YNBY. Except for this effect, analgesia and anti-infection may be new research directions of this formula. In addition, the in vitro and in vivo pharmacology and mechanisms of action of YNBY are encouraged as well as the pharmacokinetics of this formulae. Furthermore, the material basis of the pharmacological effects of YNBY also needs clear identification.
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Inflammatory bowel disease (IBD), comprised of Crohn’s disease (CD) and ulcerative colitis (UC), is a group of chronic inflammatory disorders. IBD is regarded as a severe healthcare problem worldwide, with high morbidity and lethality. So far, despite of numerous studies on this issue, the specific mechanisms of IBD still remain unclarified and ideal treatments are not available for IBD. The intestinal mucosal barrier is vital for maintaining the function of the intestinal self-defensive system. Among all of the components, macrophage is an important one in the intestinal self-defensive system, normally protecting th...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
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