GSE184713 Melatonin Enhances Osteoblastogenesis from Senescent Mesenchymal Stem Cells via NSD2 Mediated Chromatin Remodeling [ChIP-seq]

Contributors : Ying Xie ; Na Han ; Feng Li ; Lijuan WangSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusFunctional crosstalk between histone modifications and chromatin remodeling has emerged as a key regulatory mode of transcriptional control during cell fate decisions, but the underlying mechanisms are not fully understood. Here we demonstrate that RUNX2 and BGLAP osteogenic genes coordinate histone H3 lysine 36 dimethylation (H3K36me2) and transcriptional elongation factor Pol II to regulate chromatin dynamic and gene transcription during osteogenesis. Mechanistically, melatonin favored osteogenic differentiation via the NSD2-mediated modification of H3K36me2 on the promoters of osteogenic driver genes in MSCs from the old donors.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Mus musculus Source Type: research