Neuroprognostic Accuracy of Quantitative Versus Standard Pupillary Light Reflex for Adult Postcardiac Arrest Patients: A Systematic Review and Meta-Analysis*

We examined whether the timing of performing quantitative pupillary light reflex or standard pupillary light reflex may impact its neuroprognostic performance in postcardiac arrest comatose patients and whether quantitative pupillary light reflex may outperform standard pupillary light reflex in early postresuscitation phase. DATA SOURCES: PubMed and Embase databases from their inception to July 2020. STUDY SELECTION: We selected studies providing sufficient data of prognostic values of standard pupillary light reflex or quantitative pupillary light reflex to predict neurologic outcomes in adult postcardiac arrest comatose patients. DATA EXTRACTION: Quantitative data required for building a 2 × 2 contingency table were extracted, and study quality was assessed using standard criteria. DATA SYNTHESIS: We used the bivariate random-effects model to estimate the pooled sensitivity and specificity of standard pupillary light reflex or quantitative pupillary light reflex in predicting poor neurologic outcome during early (
Source: Critical Care Medicine - Category: Emergency Medicine Tags: Review Articles Source Type: research

Related Links:

AbstractGeneral anesthesia is a reversible drug-induced state of altered arousal characterized by loss of responsiveness due to brainstem inactivation. Precise identification of the moment in which responsiveness is lost during the induction of general anesthesia is extremely important to provide information regarding an individual ’s anesthetic requirements and help intraoperative drug titration. To characterize the transition from responsiveness to unresponsiveness more objectively, we studied neurophysiologic-derived parameters of electromyographic records of electrically evoked blink reflex as a means of identify...
Source: Journal of Clinical Monitoring and Computing - Category: Information Technology Source Type: research
AbstractMeasurement of pupillary characteristics, such as pupillary unrest in ambient light, and reflex dilation have been shown to be useful in a variety of clinical situations. Dedicated pupillometers typically capture images in the near-infrared to allow imaging in both light and darkness. However, because a subset of pupillary measurements can be acquired with levels of visible light suitable for conventional cameras, it is theoretically possible to capture data using general purpose cameras and computing devices such as those found on smartphones. Here we describe the development of a smartphone-based pupillometer and...
Source: Journal of Clinical Monitoring and Computing - Category: Information Technology Source Type: research
J Dent Res. 2021 Oct 23:220345211047510. doi: 10.1177/00220345211047510. Online ahead of print.ABSTRACTThe emergence of the COVID-19 viral pandemic has generated a renewed interest in pharmacologic agents that target the renin angiotensin system (RAS). Angiotensin-converting enzyme 1 (ACE1) inhibitors decrease the synthesis of angiotensin II (Ang II) from its precursor angiotensin I and inhibit the breakdown of bradykinin, while Ang II receptor blockers antagonize the action of Ang II at the receptor level downstream. The actions of both classes of drugs lead to vasodilation, a blunting of sympathetic drive and a reduction...
Source: Cell Research - Category: Cytology Authors: Source Type: research
Contributors : Mark W Zimmerman ; Adam D Durbin ; Shuning He ; Alla Berezovskaya ; Felix Oppel ; Hui Shi ; Ting Tao ; Zhaodong Li ; Yu Liu ; Jinghui Zhang ; Richard A Young ; Brian J Abraham ; A T LookSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensNeuroblastoma cell identity depends on a core regulatory circuit (CRC) of transcription factors that incorporate MYCN to drive the oncogenic gene expression program. For neuroblastomas dependent on the adrenergic CRC, treatment with retinoids can inhibit cell growth and induce differentiation in both primary neuroblastomas and...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Homo sapiens Source Type: research
Contributors : Mark W Zimmerman ; Adam D Durbin ; Shuning He ; Alla Berezovskaya ; Felix Oppel ; Hui Shi ; Ting Tao ; Zhaodong Li ; Yu Liu ; Jinghui Zhang ; Richard A Young ; Brian J Abraham ; A T LookSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensNeuroblastoma cell identity depends on a core regulatory circuit (CRC) of transcription factors that incorporate MYCN to drive the oncogenic gene expression program. For neuroblastomas dependent on the adrenergic CRC, treatment with retinoids can inhibit cell growth and induce differentiation in both primary neuroblastomas and cell lines; h...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Contributors : Mark W Zimmerman ; Adam D Durbin ; Shuning He ; Alla Berezovskaya ; Felix Oppel ; Hui Shi ; Ting Tao ; Zhaodong Li ; Yu Liu ; Jinghui Zhang ; Richard A Young ; Brian J Abraham ; A T LookSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensNeuroblastoma cell identity depends on a core regulatory circuit (CRC) of transcription factors that incorporate MYCN to drive the oncogenic gene expression program. For neuroblastomas dependent on the adrenergic CRC, treatment with retinoids can inhibit cell growth and induce differentiation in both primary neuroblastomas and...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Homo sapiens Source Type: research
The β3-AR is a GPCR expressed in most segments of the murine nephron, where it modulates cAMP production. We investigate β3-AR potential as therapeutic target in ADPKD and show that targeted β3-AR blockade leads to a reduction in kidney/body weight through a decrease in total cAMP renal levels in a m ouse model of ADPKD. Furthermore we report evidence of β3-AR presence in biopsies from healthy and ADPKD patients. AbstractAutosomal dominant polycystic kidney disease (ADPKD) disrupts renal parenchyma through progressive expansion of fluid-filled cysts. The only approved pharmacotherapy for ADKPD involves ...
Source: Physiological Reports - Category: Physiology Authors: Tags: ORIGINAL ARTICLE Source Type: research
We examined the link between increased intra-abdominal pressure, intracranial pressure, and vasopressin release as a potential mechanism. Intra-abdominal pressure, produced by abdominal-cavity insufflation with carbon dioxide (CO2) during laparoscopic abdominal procedures to facilitate visualization, is associated with various complications, including arterial hypertension and oliguria.
Source: Surgery - Category: Surgery Authors: Source Type: research
Exp Brain Res. 2021 Oct 22. doi: 10.1007/s00221-021-06243-0. Online ahead of print.ABSTRACTSpinal DC stimulation (tsDCS) shows promise as a technique for the facilitation of functional recovery of motor function following central nervous system (CNS) lesion. However, the network mechanisms that are responsible for the effects of tsDCS are still uncertain. Here, in a series of experiments, we tested the hypothesis that tsDCS increases the excitability of the long-latency stretch reflex, leading to increased excitability of corticospinal neurons in the primary motor cortex. Experiments were performed in 33 adult human subjec...
Source: Experimental Brain Research - Category: Neuroscience Authors: Source Type: research
J Physiol. 2021 Oct 22. doi: 10.1113/JP282386. Online ahead of print.NO ABSTRACTPMID:34676561 | DOI:10.1113/JP282386
Source: The Journal of Physiology - Category: Physiology Authors: Source Type: research
More News: Brain | Databases & Libraries | Emergency Medicine | Neurology | Reflex Sympathetic Dystrophy | Study