In silico screening of potent inhibitors against COVID-19 key targets from a library of FDA-approved drugs

In this study, we virtually screened a library of FDA-approved drugs prescribed for different therapeutic purposes against versatile COVID-19 specific proteins which are crucial for the virus life cycle. Three antibiotics in our screening polymyxin B, bafilomycin A, and rifampicin show motivating binding stability with more than one target of the virus. Another category of tested drugs is oral antiseptics of mouth rinsing solutions that unexpectedly exhibited significant affinity to the target proteins employed by the virus for attachment and cell internalization. Other OTC drugs widely used and tested in our study are heartburn drugs and they show no significant binding. We tested also some other drugs falling under the scope of investigation regarding interference with a degree of severity of COVID-19 like angiotensin II blockers used as antihypertensive, and our study suggests a therapeutic rather than predisposing effect of these drugs against COVID-19.PMID:34562220 | DOI:10.1007/s11356-021-16427-4
Source: Environmental Science and Pollution Research International - Category: Environmental Health Authors: Source Type: research

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Abe Oudshoorn, Tanya Benjamin, Tracy A. Smith-Carrier, Sarah Benbow, Carrie Anne Marshall, Riley Kennedy, Jodi Hall, C. Susana Caxaj, Helene Berman, Deanna Befus Housing, Care and Support, Vol. ahead-of-print, No. ahead-of-print, pp.- People experiencing homelessness are uniquely vulnerable to the impacts of a pandemic, such as COVID-19. Therefore, governments across Canada have been implementing a patchwork of responses to address the needs of those who are homeless at this time. The purpose of this study is to both compile and assess the varying responses by exploring the breadth of actions presented i...
Source: Housing, Care and Support - Category: International Medicine & Public Health Authors: Source Type: research
ConclusionIn the follow-up of children and adolescents with CCM during the first UK lockdown using telemedicine we found that over half had stable health conditions. Patients needing additional care could not be predicted by the severity of their disease or their bowel function alone.
Source: Pediatric Surgery International - Category: Surgery Source Type: research
A new"rapid expert consultation" has identified"actionable guidance" that state and local decision-makers can use to communicate with the public.Medscape Medical News
Source: Medscape Pediatrics Headlines - Category: Pediatrics Tags: Pediatrics News Source Type: news
At Legacy, fewer than 500 employees are not vaccinated.
Source: bizjournals.com Health Care News Headlines - Category: Health Management Authors: Source Type: news
In this study, we virtually screened a library of FDA-approved drugs prescribed for different therapeutic purposes against versatile COVID-19 specific proteins which are crucial for the virus life cycle. Three antibiotics in our screening polymyxin B, bafilomycin A, and rifampicin show motivating binding stability with more than one target of the virus. Another category of tested drugs is oral antiseptics of mouth rinsing solutions that unexpectedly exhibited significant affinity to the target proteins employed by the virus for attachment and cell internalization. Other OTC drugs widely used and tested in our study are hea...
Source: Cell Research - Category: Cytology Authors: Source Type: research
Every week, Shellie Fry carefully plans out each meal she, her 81-year-old father, and her 30-year-old son will eat. She buys the least amount of food she thinks they can manage because money has been tight since her father lost his job cleaning charter buses in March, after the pandemic hit. Without health insurance, she pays out of pocket for the medications she needs for her bipolar disorder, heartburn and blood pressure, and by the time the family pays its other bills, as well as her father’s Medicare contribution and medications, there is little money left. “I’ve had a few times where I just didn&rsq...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Source Type: news
Queasy Americans, fighting upset stomachs and worries about the pandemic, have stocked up on prescription and over-the-counter medications, making them scarce in some parts of the country.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Johnson & GlaxoSmithKline PLC Wegmans Coronavirus (2019-nCoV) Heartburn Drugs (Pharmaceuticals) Stockpiling Gastroesophageal Reflux (Acid Reflux) pepcid antacid tums Source Type: news
While most people are familiar with the hallmark symptoms of COVID-19 by now—cough, fever, muscle aches, headaches and difficulty breathing—a new crop of medical conditions are emerging from the more than 4 million confirmed cases of the disease around the world. These include skin rashes, diarrhea, kidney abnormalities and potentially life-threatening blood clots. It’s not unusual for viruses to directly infect and affect different tissues and organs in the body, but it is a bit unusual for a primarily respiratory virus like SARS-CoV-2, which is responsible for COVID-19, to have such a wide-ranging reach...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized COVID-19 Source Type: news
(CNN) — The US Food and Drug Administration is requesting that manufacturers pull all prescription and over-the-counter ranitidine drugs, known by the brand name Zantac, from the market immediately, the agency announced on Wednesday. The FDA noted that an ongoing investigation has determined that levels of a contaminant in the heartburn medications increase over time and when stored at higher-than-normal temperatures, poses a risk to public health. The contaminant, N-nitrosodimethylamine or NDMA, is a probable human carcinogen and the FDA has been investigating levels of it in ranitidine since the summer of 2019. &ld...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Health News Syndicated CBSN Boston CNN Zantac Source Type: news
BOSTON (CBS) – As concerns about the spread of the novel coronavirus mount, many people are left wondering if there’s anything they can do. And no, the answer is not to get your hands on a face mask. Face masks are useful when worn by people who are already sick to prevent the spread of germs, but not very helpful for healthy people trying to avoid getting sick. So forget the face masks and focus on the basics. Read: Answers To Your Coronavirus Questions According to the U.S. Department of Homeland Security, one important step is to make sure you have everything you need at home in the event you have to sh...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Boston News Health Healthwatch Syndicated CBSN Boston Syndicated Local Coronavirus Dr. Mallika Marshall Source Type: news
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