Transverse tubule remodelling in the atrophied left ventricle in right ‑sided heart failure

We examined remodelling across tissue anatomical regions of both ventricles: trabeculae, papillary muscles, and free walls. Our analyses demonstrated in MCT hearts significant loss of t-tubule periodicity, disruption of the normal sarcomere striated pattern with JPH2 labelling, and also a disorganised striated pattern of RyR2 - a feature not previously reported in heart failure. Remodelling of JPH2 and RyR2 in the MCT heart was more pronounced in papillary muscles and trabeculae - particularly in the left ventricle, indicating that these anatomical structures, used as ex vivo isolated muscle preparations, are more sensitive to the disease process.PMID:34559582 | DOI:10.1152/ajpheart.00298.2021
Source: American Journal of Physiology. Heart and Circulatory Physiology - Category: Physiology Authors: Source Type: research