New World Leishmania spp. infection in people living with HIV: concerns about relapses and secondary prophylaxis
This study investigated patients with HIV/ATL and HIV/VL to describe the outcome of leishmaniasis in patients assisted at a referral hospital of Brazilian midwestern region. Patients with HIV/ATL (n = 21) mainly presented cutaneous diseases (76.2%) with an overall relapse rate of 28.57% after treatment, whereas HIV/VL (n = 28) patients accounted for 17.5% of the cases. The counts of CD4+ T cells and CD8+ T cells and the CD4+/CD8+ cell ratios at diagnosis or relapses were not significantly different between relapsing and non-relapsing patients. Patients with HIV/ATL or HIV/VL showed high levels of activation markers in CD4+ and CD8+ T cells. The regular use of highly active antiretroviral therapy (HAART) and viral load at the time of diagnosis did not influence the relapse rates. Relapses occurred in 36.4% (4/11) of the patients with HIV/VL receiving secondary prophylaxis and in 5.9% (1/17) of the patients who did not receive secondary prophylaxis (p = 0.06). These data are relevant for the therapeutic management of the patients coinfected with HIV/Leishmania.PMID:34562423 | DOI:10.1016/j.actatropica.2021.106146
Source: Acta Tropica - Category: Infectious Diseases Authors: Camila Freire Ara újo Iara Barreto Neves Oliveira Muriel Vilela Teodoro Silva Ledice In ácia de Araújo Pereira Sebasti ão Alves Pinto Murilo Barros Silveira Miriam Leandro Dorta Simone Gon çalves Fonseca Rodrigo Saar Gomes F átima Ribeiro-Dias Source Type: research