Significantly less inappropriate shocks in ischemic patients compared to non ‐ischemic patients: The S‐ICD experience of a high volume single‐center

ConclusionIn this real-world prospective registry we analyzed S-ICD performance in the more traditional ICD patient. Patients with ischemic cardiomyopathy had significantly less inappropriate therapy compared to patients with non-ischemic cardiomyopathy and appear to be appropriate patients for this type of device.
Source: Pacing and Clinical Electrophysiology : PACE - Category: Cardiology Authors: Tags: ORIGINAL ‐ DEVICES Source Type: research

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ConclusionIn this real world prospective registry we analysed S-ICD performance in the more traditional ICD patient. Patients with ischemic cardiomyopathy had significantly less inappropriate therapy compared to patients with non-ischemic cardiomyopathy and appear to be appropriate patients for this type of device.This article is protected by copyright. All rights reserved
Source: Pacing and Clinical Electrophysiology : PACE - Category: Cardiology Authors: Tags: ORIGINAL ‐ DEVICES Source Type: research
Experience on atrial fibrillation in the young (AFY) is scarce. Prevalence of “lone AF” has been reported as 7.5 per 100.000 children while the definition of “lone AF” remained elusive (1). In the current issue of Heart Rhythm Journal, El Assaad et al. (2) publish a retrospective analysis on management and outcomes of atrial fibrillation in 241 healthy children and yo ung adults facilitated by the Pediatric and Congenital Electrophysiology Society (PACES). Inclusion into this study on AFY were absence of structural heart disease, cardiomyopathy, ventricular preexcitation, history of open heart surge...
Source: Heart Rhythm - Category: Cardiology Authors: Source Type: research
CONCLUSION: High performance was obtained by using DPS-Net in LV detection and LVEF measurement for heart failure with several phenotypes. High performance was observed in a large-scale dataset, suggesting that the DPS-Net was highly adaptive across different echocardiographic systems.PMID:34170197 | DOI:10.1152/ajpheart.00416.2020
Source: American Journal of Physiology. Heart and Circulatory Physiology - Category: Physiology Authors: Source Type: research
CONCLUSIONOf the LBBB electrocardiographic criteria analyzed in this study, QRS duration ≥150 ms and left axis deviation were the best predictors of dyssynchrony individually and in association. Table 1: ResultsQRS120/149QRS ≥150QSV1Notch/SLeftAxisQSV1+≥150Notch/S+≥150LeftAxis+≥150Nº Patients2917272625131110Synchronous5(17%)2(16%)3(11%)5(19%)1 (4%)2(15%)1(9%)0Intermediate6(20 %)1(8%)4(15%)2(7%)2(8%)1(8%)1(9%)0Asynchronous18(63%)14(82%)20(74%)19(74%)22(88%)10(77%)9(82%)10(100%)Abstract Figure. synchronous and asynchronous LBBB
Source: Europace - Category: Cardiology Source Type: research
Exp Ther Med. 2021 Jul;22(1):678. doi: 10.3892/etm.2021.10110. Epub 2021 Apr 25.ABSTRACTDiabetic cardiomyopathy (DCM) is the leading cause of death worldwide, and oxidative stress was discovered to serve an important role in the pathophysiology of the condition. An imbalance between free radicals and antioxidant defenses is known to be associated with cellular dysfunction, leading to the development of various types of cardiac disease. Nuclear factor-erythroid-2-related factor 2 (NRF2) is a transcription factor that controls the basal and inducible expression levels of various antioxidant genes and other cytoprotective pha...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Authors: Source Type: research
Am J Manag Care. 2021 Apr;27(6 Suppl):S118-S125. doi: 10.37765/ajmc.2021.88629.ABSTRACTHypertrophic cardiomyopathy (HCM) is often seen in patients as an autosomal dominant genetic heart disease with a variable clinical course. It is characterized by left ventricular hypertrophy, and with some patients, there is no evidence of a genetic etiology or presence of HCM in family members. Young age at diagnosis and the presence of a pathogenic or likely pathogenic sarcomere variant predict greater lifelong risk for stroke, heart failure, ventricular arrhythmia, atrial fibrillation, or mortality. Most individuals affected with HCM...
Source: The American Journal of Managed Care - Category: Health Management Authors: Source Type: research
AbstractAtrial fibrillation (AF) and heart failure (HF) represent clinical turning points, altering the natural history of HCM and influencing long-term outcome of the disease. The aim of this study was to evaluate the ability of left ventricular (LV) and left atrial (LA) myocardial deformation parameters to predict new-onset AF and HF outcomes in patients with HCM. This was a prospective study that included HCM patients without severe valvular heart disease, prior myocardial infarction or history of AF. The study sample consisted of 250 patients (mean age 50.8  ± 15.8, 67.2% male). Two-dimensional (2D...
Source: The International Journal of Cardiovascular Imaging - Category: Radiology Source Type: research
CONCLUSION: Our report expands the cardiac phenotype of CACNA1C variants and reflects the variable expressivity of mutations in the L-type Ca2+ channel.PMID:33797204 | DOI:10.1002/mgg3.1673
Source: Molecular Medicine - Category: Molecular Biology Authors: Source Type: research
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