Assessment of Quality of Life 8-Dimension (AQoL-8D): translation, validation and application in two Dutch trials in patients with epilepsy and schizophrenia

CONCLUSION: Our results have shown that, amongst other things, AQoL-8D presents better ability to discriminate between known-groups and shows no ceiling effect. Based on our results, we would recommend use of AQoL-8D in addition to EQ-5D-5L in trials assessing patient's quality of life in patients with epilepsy or schizophrenia.PMID:34553651 | DOI:10.1080/14737167.2021.1981861
Source: Expert Review of Pharmacoeconomics and Outcomes Research - Category: Health Management Authors: Source Type: research

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Scientists have long understood that the region of the brain called the hippocampus is important for memory, learning and navigation.Now, scientists in a UCLA lab led by neurophysicist Mayank Mehta are gaining a deeper understanding of how the hippocampus works on a circuit level — that is, functions involving networks of millions of neurons. That knowledge could be an important step toward the development of treatments for neurological disorders such as Alzheimer’s disease, schizophrenia and epilepsy, all of which are related to dysfunction in the hippocampus.In their latest study, published in the journal Nat...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news
Gene. 2021 Oct 18:146021. doi: 10.1016/j.gene.2021.146021. Online ahead of print.ABSTRACTThe GABA receptors represent the main inhibitory system in the central nervous system that ensure synaptogenesis, neurogenesis, and the regulation of neuronal plasticity and learning. GABAA receptors are pentameric in structure and belong to the Cys-loop superfamily. The GABRB2 gene, located on chromosome 5q34, encodes the β2 subunit that combines with the α and γ subunits to form the major subtype of GABAA receptors, which account for 43% of all GABAA receptors in the mammalian brain. Each subunit probably consists of...
Source: Gene - Category: Genetics & Stem Cells Authors: Source Type: research
AbstractMolecules that selectively act on N-methyl-D-aspartate (NMDA) receptors may have a multidirectional effect by modulating the activity of NMDARs, affecting their active sites as well as by changing the composition of their subunits. The results of the clinical trials conducted so far in mood disorders and schizophrenia indicate that such agents may become new effective drugs for the treatment of these diseases. Number of spider neurotoxins e.g. ctenitoxins extracted fromPhoneutria sp. venom act as potent and selective NMDAR blockers that do not disturb cortical and hippocampal glutamate signaling, LTP generation and...
Source: NeuroMolecular Medicine - Category: Neurology Source Type: research
Neuropharmacology. 2021 Sep 21:108805. doi: 10.1016/j.neuropharm.2021.108805. Online ahead of print.ABSTRACTConsiderable genetic variation of N-methyl-d-aspartate receptors (NMDARs) has recently become apparent, with many hundreds of de novo variants identified through widely available clinical genetic testing. Individuals with GRIN variants present with neurological conditions such as epilepsy, autism, intellectual disability (ID), movement disorders, schizophrenia and behavioral disorders. Determination of the functional consequence of genetic variation for NMDARs should lead to precision therapeutics. Furthermore, genet...
Source: Neuropharmacology - Category: Drugs & Pharmacology Authors: Source Type: research
CONCLUSION: Our results have shown that, amongst other things, AQoL-8D presents better ability to discriminate between known-groups and shows no ceiling effect. Based on our results, we would recommend use of AQoL-8D in addition to EQ-5D-5L in trials assessing patient's quality of life in patients with epilepsy or schizophrenia.PMID:34553651 | DOI:10.1080/14737167.2021.1981861
Source: Expert Review of Pharmacoeconomics and Outcomes Research - Category: Health Management Authors: Source Type: research
CONCLUSION: Our results have shown that, among other things, AQoL-8D presents better ability to discriminate between known-groups and shows no ceiling effect. Based on our results, we would recommend the use of AQoL-8D in addition to EQ-5D-5L in trials assessing patient's quality of life in patients with epilepsy or schizophrenia.PMID:34553651 | DOI:10.1080/14737167.2021.1981861
Source: Expert Review of Pharmacoeconomics and Outcomes Research - Category: Health Management Authors: Source Type: research
In conclusion, antagonism between psychosis and epileptic seizures in a later stage of active epilepsy seems not to be realized without reorganization of the nervous system promoted during an earlier stage. Both genetic predisposition and the summated effects of epileptic activity must be taken into consideration as part of a trial to explain interictal psychosis. Interictal psychosis is an aggregate of miscellaneous disorders, that is, co-morbid schizophrenia, AED-induced psychotic disorders, forced normalization, and "epileptic" interictal psychosis. Data are lacking to conclude whether differences exist betwee...
Source: Epilepsy Curr - Category: Neurology Authors: Source Type: research
CONCLUSION: These findings demonstrate the first large quantitative evidence on the unique psychopathology of IIP which has been only narratively described. The psychopathology is associated with the interaction between epilepsy-related and psychosis-general effects.PMID:34375801 | DOI:10.1016/j.yebeh.2021.108214
Source: Epilepsy and Behaviour - Category: Neurology Authors: Source Type: research
Chest. 2021 Aug;160(2):e205-e208. doi: 10.1016/j.chest.2021.03.071.ABSTRACTA 48-year-old man presented with 6 months of progressive shortness of breath, intermittent exertional left-sided chest pain, and bilateral lower extremity edema. During the 2 days before admission, he experienced new onset confusion, fatigue, and malaise that prompted evaluation. He denied fever, chills, cough, or sputum production. He used anabolic steroids for 20 years as part of his bodybuilding hobby. Recently, he also began injecting mineral oil into his pectoral, bicep, and shoulder muscles for an improved muscular appearance. Additionally, he...
Source: Chest - Category: Respiratory Medicine Authors: Source Type: research
Stepulak Valproic acid (2-propylpentanoic acid, VPA) is a short-chain fatty acid, a member of the group of histone deacetylase inhibitors (HDIs). VPA has been successfully used in the treatment of epilepsy, bipolar disorders, and schizophrenia for over 50 years. Numerous in vitro and in vivo pre-clinical studies suggest that this well-known anticonvulsant drug significantly inhibits cancer cell proliferation by modulating multiple signaling pathways. Breast cancer (BC) is the most common malignancy affecting women worldwide. Despite significant progress in the treatment of BC, serious adverse effects, high toxicity to...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research
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