Monocyte transcriptomes from patients with axial spondyloarthritis reveal dysregulated monocytopoiesis and a distinct inflammatory imprint
CONCLUSIONS: The neutrophil-like phenotype of axSpA monocytes points towards a biased monocytopoiesis from granulocyte-monocyte progenitors. This shift in monocytopoiesis and the LPS/cytokine imprint as well as the elevated LBP levels are indicators of systemic inflammation, which may result from bacterial translocation. The BM adaptation is most prominent in AS patients while disease activity appears to be linked to activation and trafficking of monocytes.PMID:34560894 | DOI:10.1186/s13075-021-02623-7
Source: Cell Research - Category: Cytology Authors: Fabian Karow Biljana Smiljanovic Joachim R Gr ün Denis Poddubnyy Fabian Proft Alice Talpin Christophe Hue Anne Boland Jean-Fran çois Deleuze Henri-Jean Garchon Ilkay Ergen ç Ann-Sophie De Craemer Ulrike Erben Thomas H äupl Dirk Elewaut Maxime Breban A Source Type: research