[Environmental and genetic risk factors for endometrial carcinoma.]

[Environmental and genetic risk factors for endometrial carcinoma.]
Bull Cancer. 2015 Feb 25;
Authors: Sénéchal C, Cottereau E, de Pauw A, Elan C, Dagousset I, Fourchotte V, Gauthier-Villars M, Lae M, Stoppa-Lyonnet D, Buecher B
Abstract
In France, endometrial cancer is at the first rank of gynecological cancers for cancer incidence, before ovarian and cervical cancers. In fact, the number of incident cases has been estimated to 7275 for the year 2012; the number of death due to endometrial cancer to 2025. This cancer is hormone-dependent and endogenous (reproductive factors) or exogenous (oral combined contraceptives, hormone replacement therapy) causes of exposition to estrogens are the major environmental risk factors for both types of endometrial cancers: type I or well-differentiated endometrioid adenocarcinomas; and type II including all other histological types: papillary serous adenocarcinomas, clear cell adenocarcinomas and carcinosarcomas, also known as malignant mixed Mullerian tumor, MMMT. Obesity, diabetes mellitus and adjuvant treatment of breast cancer with tamoxifen are also associated with an increased risk of endometrial cancer. Genetic factors may also be implicated in the pathogenesis of endometrial cancer either as "minor genetic factors" (susceptibility factors), which remain largely unknown and are responsible for the increased observed risk in relatives of women affected with endometrial cancer; or as major...

Source: Bulletin du Cancer - February 25, 2015 Category: Cancer & Oncology Authors: Sénéchal C, Cottereau E, de Pauw A, Elan C, Dagousset I, Fourchotte V, Gauthier-Villars M, Lae M, Stoppa-Lyonnet D, Buecher B Tags: Bull Cancer Source Type: research