GSE159025 Neurofibromin (Nf1) controls metabolic balance and Notch-dependent quiescence of murine juvenile myogenic progenitors [MeDIP-Seq]

Contributors : Xiaoyan Wei ; Sigmar StrickerSeries Type : Methylation profiling by high throughput sequencingOrganism : Mus musculusWe conclude that the epigenetic alterations we observed in Nf1Myf5 MPs are in line with a shift towards a quiescent state, and that these alterations could contribute to impaired myogenic differentiation. Furthermore, hypermethylation and transcriptional downregulation of metabolic genes points towards changes in cellular energy metabolism in Nf1Myf5 MPs.

Source: GEO: Gene Expression Omnibus - September 25, 2021 Category: Genetics & Stem Cells Tags: Methylation profiling by high throughput sequencing Mus musculus Source Type: research