Poisonings rise as Americans treat Covid with anti-parasitic drug

Ivermectin has been touted by conservative commentators despite not being approved for use against virus
Source: FT.com - Drugs and Healthcare - Category: Pharmaceuticals Source Type: news

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Funding Opportunity RFA-AI-21-075 from the NIH Guide for Grants and Contracts. To expand our understanding of protozoan parasite persistence mechanisms and provide research tools and strategies to enable identification and credentialing of novel treatments for persistent protozoan pathogens.
Source: NIH Funding Opportunities (Notices, PA, RFA) - Category: Research Source Type: funding
Ivermectin is an over 30-year-old wonder drug that treats life- and sight-threatening parasitic infections. Its lasting influence on global health has been so profound that two of the key researchers in its discovery and development won the Nobel Prize in 2015. I ’ve been an infectious disease pharmacist for over 25 years. I’ve also managed patientsRead more …Ivermectin is a Nobel Prize-winning wonder drug originally appeared inKevinMD.com.
Source: Kevin, M.D. - Medical Weblog - Category: General Medicine Authors: Tags: Meds Infectious Disease Source Type: blogs
CONCLUSIONS: Real-time PCR testing of scrapings and dermoscopy are more effective than microscopy. Combined real-time PCR testing of scrapings and skin swabs seemed the most effective. Clinical signs alone should not be used as unambiguous criteria.PMID:34658697 | PMC:PMC8501433 | DOI:10.5114/ada.2020.94275
Source: Advances in Dermatology and Allergology - Category: Dermatology Authors: Source Type: research
Parasitol Res. 2021 Oct 18. doi: 10.1007/s00436-021-07341-2. Online ahead of print.ABSTRACTBiomphalaria spp. snails are intermediary hosts of Schistosoma mansoni, etiologic agent of intestinal schistosomiasis, one of the most important neglected tropical diseases. Biomphalaria straminea is an important intermediary host that possess a different phenotype to parasite infection but shows a large geographic distribution and high capacity of new ecologic niche invasion. Our purpose was to characterize for the first time the differentially expressed proteome in B. straminea during two times intervals after primary and secondary...
Source: Cell Research - Category: Cytology Authors: Source Type: research
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Source: Protein Science - Category: Biochemistry Authors: Tags: Full ‐Length Paper Source Type: research
Although macrophages are considered for host cells for the multiplication of Leishmania, recent studies indicate the important role of neutrophil granulocytes as host cells for these intracellular parasites. Neutrophils have been shown to be massively and rapidly recruited to the site of Leishmania infection where they represent the first cells to encounter the parasites. Exposure to ATP and UTP have been shown to enhance anti-Leishmania activity of macrophages and intralesional injection of UTP led to strongly reduced parasite load in vivo. Since the in vivo anti-leishmanial effect of extracellular UTP correlated with enh...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
In this study, we explored the APC-targeting strategy for a PfRH5ΔNL-containing DNA vaccine. BALB/c mice immunized with the targeted vaccine induced higher PfRH5-specific IgG1 antibody responses than those vaccinated with a non-targeted vaccine or antigen alone. The APC-targeted vaccine also efficiently induced rapid IFN-γ and IL-4 T cell responses. Furthermore, the vaccine-induced PfRH5-specific IgG showed inhibition of growth of the P. falciparum 3D7 clone parasite in vitro. Finally, sera obtained after vaccination with this targeted vaccine competed for the same epitopes as PfRH5-specific mAbs from vaccinate...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Clonorchiasis, which is caused by Clonorchis sinensis, is an important foodborne disease worldwide. The excretory-secretory products (ESPs) of C. sinensis play important roles in host-parasite interactions by acting as causative agents. In the present study, the ESPs and sera positive for C. sinensis were collected to identify proteins specific to the sera of C. sinensis (i.e., proteins that do not cross-react with Fasciola hepatica and Schistosoma japonicum) at different infection periods. Briefly, white Japanese rabbits were artificially infected with C. sinensis, and their sera were collected at 7 days post-infection (d...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
Molecules, Vol. 26, Pages 6294: Lipid A-Mediated Bacterial–Host Chemical Ecology: Synthetic Research of Bacterial Lipid As and Their Development as Adjuvants Molecules doi: 10.3390/molecules26206294 Authors: Atsushi Shimoyama Koichi Fukase Gram-negative bacterial cell surface component lipopolysaccharide (LPS) and its active principle, lipid A, exhibit immunostimulatory effects and have the potential to act as adjuvants. However, canonical LPS acts as an endotoxin by hyperstimulating the immune response. Therefore, LPS and lipid A must be structurally modified to minimize their toxic effects while maintaini...
Source: Molecules - Category: Chemistry Authors: Tags: Review Source Type: research
by Gil Benedek, Mahmoud Abed El Latif, Keren Miller, Mila Rivkin, Ally Ahmed Ramadhan Lasu, Lul P. Riek, Richard Lako, Shimon Edvardson, Sagit-Arbel Alon, Eithan Galun, Mia Levite Nodding syndrome (NS) is a catastrophic and enigmatic childhood epilepsy, accompanied by multiple neurological impairments and neuroinflammation. Of all the infectious, environmental and psychological factors associated with NS, the major culprit is Onchocerca Volvulus (Ov)–a parasitic worm tran smitted to human by blackflies. NS seems to be an ’Autoimmune Epilepsy’ in light of the recent findings of deleterious autoimmune anti...
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
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