Obesity induces morphological and functional changes in female reproductive system through increases in NF- κB and MAPK signaling in mice

CONCLUSIONS: These HFD-induced increases in pro-inflammatory cytokine expression levels and NF-κB and MAPKs signaling pathway activation in reproductive organs support the notion that increases of adipocytes resident and inflammatory status are symptomatic of female fertility impairment in obese mice.PMID:34560886 | DOI:10.1186/s12958-021-00833-x
Source: Reproductive Biology - Category: Reproduction Medicine Authors: Source Type: research

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ConclusionThe present results demonstrates that HFD causes obesity-driven testicular dysfunction, associated with testicular lipid deposition, oxidative stress, and inflammation. The study in addition suggests the restoration of testicular function in obese animals by acetate, an effect that is accompanied by elevated Nrf2/PPAR- γ.
Source: Journal of Diabetes and Metabolic Disorders - Category: Endocrinology Source Type: research
Endocrinology. 2021 Oct 1:bqab209. doi: 10.1210/endocr/bqab209. Online ahead of print.ABSTRACTAltered nutrition or intra-uterine exposure to various adverse conditions during fetal development or earlier in a mother's life can lead to epigenetic changes in fetal tissues, predisposing those tissues to diseases that manifest when offspring become adults. An example is a maternal obesity associated with gestational diabetes (GDM), where fetal exposure to a hyperglycemic, hyperinsulinemic, and/or hyperlipidemic gestational environment can provoke epigenetic changes that predispose offspring to various diseased conditions later...
Source: Endocrinology - Category: Endocrinology Authors: Source Type: research
Chiara Tortora Anti-cancer treatments improve survival in children with cancer. A total of 80% of children treated for childhood cancer achieve 5-year survival, becoming long-term survivors. However, they undergo several chronic late effects related to treatments. In childhood cancer survivors a chronic low-grade inflammation, known as inflamm-aging, is responsible for frailty, a condition characterized by vital organ failure and by premature aging processes. Inflamm-aging is closely related to chemotherapy and radiotherapy, which induce inflammation, accumulation of senescent cells, DNA mutations, and the productio...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research
Conclusion(s). BMI showed no impact on the outcome of the ovarian stimulation outcome in PPOS protocol. PPOS protocol may benefit overweight patients, for it attains the same effect with normal patients and requires no increase in gonadotropin (Gn) dose and Gn duration.PMID:34584537 | PMC:PMC8470839 | DOI:10.1155/2021/9979972
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Authors: Source Type: research
J Clin Med. 2021 Sep 18;10(18):4243. doi: 10.3390/jcm10184243.ABSTRACTWe aimed to study whether lifestyle intervention could reduce systemic oxidative stress (OS) and the association between OS and cardiometabolic outcomes in women with obesity and infertility. From 2009 to 2012, infertile women with a BMI ≥ 29 kg/m2 were randomly assigned to a six-month lifestyle intervention followed by infertility treatment (N = 289) or to prompt infertility treatment (N = 285). Fasting serum free thiols (FT) concentrations were determined by colorimetry at baseline, at three and six months after randomization. Generalized estimating...
Source: Molecular Medicine - Category: Molecular Biology Authors: Source Type: research
The purpose of this American Society for Reproductive Medicine Practice Committee report is to provide clinicians with principles and strategies for the evaluation and treatment of couples with infertility associated with obesity. This revised document replaces the Practice Committee document titled “Obesity and reproduction: an educational bulletin” last published in 2015 (Fertil Steril 2015;104:1116–26).
Source: Fertility and Sterility - Category: Reproduction Medicine Authors: Tags: ASRM pages Source Type: research
Recently, human infertility incidence is increasing in obese women causing it to become an emerging global health challenge requiring improved treatment. There is extensive evidence that obesity caused female ...
Source: Reproductive Biology and Endocrinology - Category: Endocrinology Authors: Tags: Research Source Type: research
Irisin is a novel skeletal muscle- and adipose tissue-secreted peptide. It is conventionally regarded as an adipomyokine and is a cleaved fragment of Fibronectin type III domain-containing protein 5 (FNDC5). It is involved in the browning of white adipose tissue, glucose tolerance, and reversing of metabolic disruptions. Fertility is closely linked to energy metabolism and the endocrine function of the adipose tissue. Moreover, there is established association between obesity and male infertility. Irisin bears strong therapeutic promise in obesity and its associated disorders, as well as shown to improve male reproductive ...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
CONCLUSIONS: In conclusion, we found that irisin alleviated obesity-related spermatogenesis dysfunction via activation of the AMPKα signalling pathway. Based on these findings, we hypothesized that irisin is a potential therapeutic agent against obesity-related spermatogenesis dysfunction.PMID:34496874 | DOI:10.1186/s12958-021-00821-1
Source: Reproductive Biology - Category: Reproduction Medicine Authors: Source Type: research
Obesity is an increasingly important contributor to infertility among women of reproductive age. It is associated with increased maternal morbidity, reduced fecundity and reduced success of infertility treatment, and requires a complex workup prior to initiation of infertility care. Infertility care itself harbors a significant financial strain on families and is not universally accessible, adding further inequity to a growing problem. Though physician counseling on excess weight is associated with clinically significant weight loss, it is engaged in irregularly, and obese women often present to infertility clinics without...
Source: Fertility and Sterility - Category: Reproduction Medicine Authors: Source Type: research
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