Barriers to Penicillin Allergy Delabeling in a Pediatric Emergency Department

It is estimated that more than 90% of children presenting to the emergency department (ED) with a parent-reported penicillin (PCN) allergy do not have true allergy;1 however, non-immunoglobulin E (IgE) mediated side effects often cannot be differentiated from true allergic reaction.1,2 “Delabeling” methods have been proposed to address misclassified PCN allergies and promote antimicrobial stewardship, optimize outcomes, and reduce costs.3 An oral PCN challenge with a single or graded two-dose is the gold standard and most rapid method for delabeling low-risk patients.

Source: Annals of Allergy, Asthma and Immunology - September 25, 2021 Category: Allergy & Immunology Authors: Jessica K. Graham, Cheryl Yang, David Vyles, Jan Leonard, Rakesh D. Mistry Tags: Letters Source Type: research