Causality imputation between herbal products and hili: an algorithm evaluation in a systematic review

Ann Hepatol. 2021 Sep 20:100539. doi: 10.1016/j.aohep.2021.100539. Online ahead of print.ABSTRACTThe algorithms can have several purposes in the clinical practice. There are different scales to causality imputation in DILI (Drug Induced Liver Injury), but the applicability and validity of these for the HILI (Herb Induced Liver Injury) evaluation is questionable for some scales. The purpose of the study was to determine the clinical and demographic profile of the patients with HILI, and the main algorithmic scales used in its causality assessment. The methodology was a systematic review of articles in English, Spanish, or Portuguese language, from 1979 to 2019, involving humans, with descriptors related to HILI. Qualitative and quantitative statistical analysis was performed. As a result, from a total of 60 articles, 203 HILI reports were selected: 59.9% were women, similar with other studies, and the average was 45.8 years. Jaundice was the most frequent symptom and regarding the type of lesion, the hepatocellular was the most frequent. About the HILI severity, 3.0% were severe and 7.6% were fatal or required liver transplantation. With 72.3% of cases, the most used algorithm was RUCAM (Roussel Uclaf Causality Assessment Method). The conclusion of the study was that the RUCAM was the most used algorithm for causality assessment in HILI. The patients were predominantly female, jaundice was the main symptom, and the HILI is reversible in the majority of cases.PMID:34555512 | DO...
Source: Annals of Hepatology - Category: Gastroenterology Authors: Source Type: research