Continued Upward Trend in Non-Tuberculous Mycobacteria Isolation over 13 Years in a Tertiary Care Hospital in Korea

CONCLUSION: The number of NTM isolates continuously increased over the study period, and the increase in the proportion of M.intracellulare in patients aged over 70 years was notable.PMID:34558869 | DOI:10.3349/ymj.2021.62.10.903
Source: Yonsei Medical Journal - Category: Universities & Medical Training Authors: Source Type: research

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Source: Infection and Drug Resistance - Category: Infectious Diseases Tags: Infection and Drug Resistance Source Type: research
Empyema may occur in the pleural space after pulmonary resection. Subsequent bacterial contamination results in infection and development of frank empyema. Pneumonectomy —surgical removal of the entire lung—is the treatment of choice for centrally located bronchogenic carcinoma, diffuse malignant mesothelioma, and chronic inflammatory lung diseases with destroyed lung from pulmonary tuberculosis, fungal infections, and bronchiectasis. In the uncomplicated case, on the pneumonectomy side, the diaphragm becomes elevated as the air–fluid level decreases with chest wall deformation and gradual disappearance o...
Source: Thoracic Surgery Clinics - Category: Cardiovascular & Thoracic Surgery Authors: Source Type: research
[Nyasa Times] The use of volunteers in community sputum collection has proven effective in the fight against tuberculosis (TB) at community level in Mchinji district.
Source: AllAfrica News: Tuberculosis - Category: Infectious Diseases Source Type: news
In conclusion, the proposed micro-nanosystem is a good candidate for the pulmonary administration of anti-TB drugs.
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
[Daily Maverick] During the 52nd Union World Conference on Lung Health this week, Doctors Without Borders announced the results of TB-PRACTECAL. A total of 89% of patients on the new regimen (which is shorter and less toxic) were cured, compared with 52% in the standard of care group.
Source: AllAfrica News: Tuberculosis - Category: Infectious Diseases Source Type: news
[Premium Times] TB has increased in strength in sub-Saharan Africa and other regions of the Global South.
Source: AllAfrica News: Tuberculosis - Category: Infectious Diseases Source Type: news
Background: While tuberculosis (TB) is curable and preventable, the most effective first-line antibiotics cannot kill multi-drug resistant (MDR) Mycobacterium tuberculosis (Mtb). Therefore, effective drugs are needed to combat MDR-TB, especially in children. Our objective was to repurpose cefazolin for MDR-TB treatment in children using principles of pharmacokinetic/pharmacodynamics (PK/PD).Methods: Cefazolin minimum inhibitory concentration (MIC) was identified in 17 clinical Mtb strains, with and without combination of the β-lactamase inhibitor, avibactam. Next, dose-ranging studies were performed using the intracel...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
As an ancient infectious disease, tuberculosis (TB) is still the leading cause of death from a single infectious agent worldwide. Latent TB infection (LTBI) has been recognized as the largest source of new TB cases and is one of the biggest obstacles to achieving the aim of the End TB Strategy. The latest data indicate that a considerable percentage of the population with LTBI and the lack of differential diagnosis between LTBI and active TB (aTB) may be potential reasons for the high TB morbidity and mortality in countries with high TB burdens. The tuberculin skin test (TST) has been used to diagnose TB for> 100 years,...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Bedaquiline (BDQ), which is recommended for the treatment of drug-resistant tuberculosis (DR-TB), was introduced in Taiwan in 2014. Due to the alarming emergence of BDQ resistance, we conducted BDQ resistance analyses to strengthen our DR-TB management program. This retrospective population-based study included initial Mycobacterium tuberculosis isolates from 898 rifampicin-resistant (RR) or multidrug-resistant (MDR) TB cases never exposed to BDQ during 2008–2019. We randomly selected 65 isolates and identified 28 isolates with BDQ MIC
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
COVID-19 cancelled out the last 12 years of advancements in finding and treating people with TB. Credit: Jeffrey Moyo/IPS. By Morounfolu OlugbosiJOHANNESBURG, Oct 21 2021 (IPS) Before COVID-19 came along, tuberculosis (TB) was a primary focus of health authorities in sub-Saharan Africa. In 2019, approximately 1.4 million people were diagnosed with TB in the region, but epidemiologists estimated that 1 million more had TB but were neither diagnosed nor treated. The scope and intensity of the global TB epidemic is fueled by antiquated and inadequate TB drugs, most of which were developed more than 50 years ago. But, given ho...
Source: IPS Inter Press Service - Health - Category: International Medicine & Public Health Authors: Tags: Africa Headlines Health Poverty & SDGs TerraViva United Nations Source Type: news
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