Interventions for treating leg ulcers in people with sickle cell disease

CONCLUSIONS: Given the very low quality of the evidence identified in this updated Cochrane Review we are uncertain whether any of the assessed pharmaceutical interventions reduce ulcer size or result in leg ulcer closure in treated participants compared to controls. However, this intervention was assessed as having a high risk of bias due to inadequacies in the single trial report. Other included studies were also assessed as having an unclear or high risk of bias. The harm profile of the all interventions remains inconclusive.PMID:34559425 | DOI:10.1002/14651858.CD008394.pub4
Source: Cochrane Database of Systematic Reviews - Category: General Medicine Authors: Source Type: research