Distinct single-component adjuvants steer human DC-mediated T-cell polarization via Toll-like receptor signaling toward a potent antiviral immune response [Immunology and Inflammation]

The COVID-19 pandemic highlights the importance of efficient and safe vaccine development. Vaccine adjuvants are essential to boost and tailor the immune response to the corresponding pathogen. To allow for an educated selection, we assessed the effect of different adjuvants on human monocyte-derived dendritic cells (DCs) and their ability to...

http://www.pnas.org/content/118/39/e2103651118.short?rss=1

Source: Proceedings of the National Academy of Sciences - September 24, 2021 Category: Science Authors: Laura Rossmann, Katrin Bagola, Tharshana Stephen, Anna–Lisa Gerards, Bianca Walber, Anȷa Ullrich, Stefan Schulke, Christel Kamp, Ingo Spreitzer, Milena Hasan, Brigitte David–Watine, Spencer L. Shorte, Max Bastian, Ger van Zandbergen Tags: Immunology and Inflammation Biological Sciences Source Type: research