Woman who dropped to four stone with rare autoimmune disease says OnlyFans money 'saved my life'
Ex legal worker Rachael Huckle, from Wrexham, says money made from racy cosplay photos have paid for private treatment for pemphigus, which causes blisters in the digestive system.
Autoimmune blistering diseases (AIBD) are severe human autoimmune diseases affecting the skin and mucous membranes (Witte et al., 2018). AIBD patients develop pathogenic autoantibodies targeting structural skin proteins and causing intraepidermal blisters to form as in pemphigus vulgaris (PV) or at the basement membrane zone (BMZ) as in pemphigoid diseases (Schmidt and Zillikens, 2011). For many AIBD, the events following autoantibody binding have been elucidated. However, early events in the pathogenic cascade leading to autoantibody production are still not fully understood.
We report a case of pemphigus vulgaris with pharyngeal ulcer as the initial presentation that was treated with glucocorticoid therapy.PMID:34657453 | DOI:10.1177/01455613211053401
Ann Dermatol. 2021 Oct;33(5):467-469. doi: 10.5021/ad.2021.33.5.467. Epub 2021 Sep 8.ABSTRACTBee-venom is composed of a variety of peptides, enzymes, and biogenic amines, and is demonstrated to have both antiinflammatory and immune-stimulatory effects in human body. Pemphigus foliaceus (PF) is a variant of pemphigus, which is a rare autoimmune bullous disease presenting with erythematous scaly crusted plaques. Although the exact pathogenesis was not identified, there have been three case reports of autoimmune disorders associated with bee-venom. In this case, a 64-year-old female was diagnosed with PF, which was developed ...
CONCLUSION: Efgartigimod was well-tolerated and exhibited an early effect on disease activity and outcome parameters, providing support for further evaluation as a therapy for pemphigus. The study is registered at ClinicalTrials.gov (identifier: NCT03334058).PMID:34608631 | DOI:10.1111/bjd.20782
The objective was to examine bacterial microbiota in autoimmune pemphigus.18 women aged 57.5±0.5 suffered from autoimmune pemphigus. 13 patients suffered from pemphigus vulgaris, 4 from seborrheic pemphigus, 1 from pemphigus vegetans. Every patient had more than 2 lesions. The bacteriological examination was performed in different areas of the skin. The scalp lesions in 2 patients with seborrheic pemphigus were contaminated by St.
The autoimmune, blistering disease pemphigus vulgaris is caused by autoantibodies against the desmosomal cadherins, mainly desmoglein-3. Recently, it has been shown that blocking the neonatal Fc receptor (FcRn) can lead to a rapid decrease of pathogenic IgG and an improvement of various autoimmune diseases, including pemphigus, myasthenia gravis and autoimmune thrombocytopenia. Binding of IgG type antibodies to FcRn results in antibody recycling and increases the plasma half-life of pathogenic autoantibodies, contributing to disease phenotype.
Pemphigus vulgaris is a chronic autoimmune blistering disease characterized by antibody production against Desmogleins 3 (Dsg3) and 1 (Dsg1) causing acantholysis. Increased levels of innate cytokines detected in the blister fluid suggest a role of innate immune system activity. To elucidate the discrepancy between binding of pathogenic antibodies and a lack of blister formation, we focused on the role of innate cofactors supporting acantholysis. Here, we used a dispase-based keratinocyte-dissociation assay with a human immortalized keratinocyte cell line (HaCaT) and human primary keratinocytes.