The Magnitude of MTB and Rifampicin Resistance MTB Using Xpert-MTB/RIF Assay Among Tuberculosis Suspected Patients in Gedeo Zone, Southern Ethiopia

Source: Infection and Drug Resistance - Category: Infectious Diseases Tags: Infection and Drug Resistance Source Type: research

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[Daily Maverick] During the 52nd Union World Conference on Lung Health this week, Doctors Without Borders announced the results of TB-PRACTECAL. A total of 89% of patients on the new regimen (which is shorter and less toxic) were cured, compared with 52% in the standard of care group.
Source: AllAfrica News: Tuberculosis - Category: Infectious Diseases Source Type: news
[Premium Times] TB has increased in strength in sub-Saharan Africa and other regions of the Global South.
Source: AllAfrica News: Tuberculosis - Category: Infectious Diseases Source Type: news
Background: While tuberculosis (TB) is curable and preventable, the most effective first-line antibiotics cannot kill multi-drug resistant (MDR) Mycobacterium tuberculosis (Mtb). Therefore, effective drugs are needed to combat MDR-TB, especially in children. Our objective was to repurpose cefazolin for MDR-TB treatment in children using principles of pharmacokinetic/pharmacodynamics (PK/PD).Methods: Cefazolin minimum inhibitory concentration (MIC) was identified in 17 clinical Mtb strains, with and without combination of the β-lactamase inhibitor, avibactam. Next, dose-ranging studies were performed using the intracel...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
As an ancient infectious disease, tuberculosis (TB) is still the leading cause of death from a single infectious agent worldwide. Latent TB infection (LTBI) has been recognized as the largest source of new TB cases and is one of the biggest obstacles to achieving the aim of the End TB Strategy. The latest data indicate that a considerable percentage of the population with LTBI and the lack of differential diagnosis between LTBI and active TB (aTB) may be potential reasons for the high TB morbidity and mortality in countries with high TB burdens. The tuberculin skin test (TST) has been used to diagnose TB for> 100 years,...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Bedaquiline (BDQ), which is recommended for the treatment of drug-resistant tuberculosis (DR-TB), was introduced in Taiwan in 2014. Due to the alarming emergence of BDQ resistance, we conducted BDQ resistance analyses to strengthen our DR-TB management program. This retrospective population-based study included initial Mycobacterium tuberculosis isolates from 898 rifampicin-resistant (RR) or multidrug-resistant (MDR) TB cases never exposed to BDQ during 2008–2019. We randomly selected 65 isolates and identified 28 isolates with BDQ MIC
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
COVID-19 cancelled out the last 12 years of advancements in finding and treating people with TB. Credit: Jeffrey Moyo/IPS. By Morounfolu OlugbosiJOHANNESBURG, Oct 21 2021 (IPS) Before COVID-19 came along, tuberculosis (TB) was a primary focus of health authorities in sub-Saharan Africa. In 2019, approximately 1.4 million people were diagnosed with TB in the region, but epidemiologists estimated that 1 million more had TB but were neither diagnosed nor treated. The scope and intensity of the global TB epidemic is fueled by antiquated and inadequate TB drugs, most of which were developed more than 50 years ago. But, given ho...
Source: IPS Inter Press Service - Health - Category: International Medicine & Public Health Authors: Tags: Africa Headlines Health Poverty & SDGs TerraViva United Nations Source Type: news
[spotlight] For the first time in over a decade, tuberculosis (TB) deaths have increased globally. This is according to the World Health Organization's Global TB Report 2021 released last week. The report found that the increase in deaths was due to "reduced access to TB diagnosis and treatment in the face of the COVID-19 pandemic".
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
[spotlight] In 1997, the then reigning world chess champion Garry Kasparov lost a six-game series to a chess-playing computer programme called Deep Blue. Deep Blue's victory was seen as emblematic of the growing power of computers to do things once thought primarily the domain of human brains.
Source: AllAfrica News: Tuberculosis - Category: Infectious Diseases Source Type: news
Conclusions: This HIV screening tool has high sensitivity and reasonable specificity, increasing testing efficiency and yield for children and adolescents.
Source: JAIDS Journal of Acquired Immune Deficiency Syndromes - Category: Infectious Diseases Tags: Implementation Science Source Type: research
CONCLUSIONS: This study reveals the coordination of pathogenic genes during TB infection and offers the diagnosis of TB a promising genome. These hub genes also provide new directions for the development of latent molecular targets for TB treatment.PMID:34671419 | PMC:PMC8523273 | DOI:10.1155/2021/8159879
Source: Computational and Mathematical Methods in Medicine - Category: Statistics Authors: Source Type: research
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