Real-time Reflectance Confocal Microscopy of Cutaneous Graft-versus-Host Disease Correlates with Histopathology

Graft-versus-host disease (GvHD) represents a leading cause of morbidity and mortality after allogeneic hematopoietic cell transplantation (allo-HCT).4-6 GvHD can lead to a high symptomatic burden, decline in functional status and poor quality of life.7,8 Cutaneous GvHD occurs frequently and is the most common presenting sign, highlighting the importance of early dermatologic diagnosis and intervention to mitigate disease progression.9 Acute GvHD (aGvHD) typically presents with a maculopapular rash whereas chronic GvHD (cGvHD) presents with poikiloderma, lichen planus-like, lichen sclerosus-like, morphea-like, and sclerotic features.

Source: Biology of Blood and Marrow Transplantation - September 24, 2021 Category: Hematology Authors: Rachel E. Reingold, Jilliana Monnier, Marco Ardig ò, Joseph R. Stoll, Maria C. Pena, Japbani K. Nanda, Stephen W. Dusza, Josel D. Ruiz, Lisa Flynn, Antara Afrin, Elizabeth G. Klein, Susan E. Prockop, Melissa P. Pulitzer, Doris M. Ponce, Alina Markova, Ma Source Type: research