Cancers, Vol. 13, Pages 4775: Radiation Therapy in Metastatic Soft Tissue Sarcoma: From Palliation to Ablation

Cancers, Vol. 13, Pages 4775: Radiation Therapy in Metastatic Soft Tissue Sarcoma: From Palliation to Ablation Cancers doi: 10.3390/cancers13194775 Authors: Nishant K. Shah Nikhil Yegya-Raman Joshua A. Jones Jacob E. Shabason The management of patients with metastatic cancer is rapidly changing. Historically, radiotherapy was utilized for the treatment of localized disease or for palliation. While systemic therapy remains the mainstay of management for patients with metastatic cancer, radiotherapy is becoming increasingly important not only to palliate symptoms, but also to ablate oligometastatic or oligoprogressive disease and improve local control in the primary site. There is emerging evidence in multiple solid malignancies that patients with low volume metastatic disease that undergo local ablative therapy to metastatic sites may have improved progression free survival and potentially overall survival. In addition, there is increasing evidence that select patients with metastatic disease may benefit from aggressive treatment of the primary site. Patients with metastatic soft tissue sarcoma have a poor overall prognosis. However, there may be opportunities in patients with low volume metastatic soft tissue sarcoma to improve outcomes with local therapy including surgery, ablation, embolization, and radiation therapy. Stereotactic body radiation therapy (SBRT) offers a safe, convenient, precise, and non-invasive option for ablation of sites of metastases. In t...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research