Viruses, Vol. 13, Pages 1923: SARS-CoV-2 Subgenomic RNAs: Characterization, Utility, and Perspectives

Viruses, Vol. 13, Pages 1923: SARS-CoV-2 Subgenomic RNAs: Characterization, Utility, and Perspectives Viruses doi: 10.3390/v13101923 Authors: Samuel Long SARS-CoV-2, the etiologic agent at the root of the ongoing COVID-19 pandemic, harbors a large RNA genome from which a tiered ensemble of subgenomic RNAs (sgRNAs) is generated. Comprehensive definition and investigation of these RNA products are important for understanding SARS-CoV-2 pathogenesis. This review summarizes the recent progress on SARS-CoV-2 sgRNA identification, characterization, and application as a viral replication marker. The significance of these findings and potential future research areas of interest are discussed.
Source: Viruses - Category: Virology Authors: Tags: Review Source Type: research

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Background: It is just over a century since the 1918 flu pandemic, sometimes referred to as the “mother” of pandemics. This brief retrospective of the 1918 pandemic is taken from the viewpoint of the current SARS-CoV-2/COVID-19 pandemic and is based on a short lecture given during the 2021 Virtual Congress of the ERA-EDTA.Summary: This review summarizes and highlights some of the earlier pandemic ’s salient features, some parallels with today, and some potential learnings, bearing in mind that the flu pandemic occurred over 100 years ago at a time of major turmoil during the climax to WWl, and with limite...
Source: Kidney and Blood Pressure Research - Category: Urology & Nephrology Source Type: research
CONCLUSIONS: This study showed that 15.6% of anti-SARS-CoV-2 ELISA positive Croatian SOTRs developed NT antibodies indicating protective immunity. Further studies are needed to determine the dynamic of NT antibodies and COVID-19 immunity duration in immunocompromised populations such as LTRs and KTRs.PMID:34658649 | PMC:PMC8495621 | DOI:10.11613/BM.2021.030901
Source: Biochemia Medica - Category: Biochemistry Authors: Source Type: research
RATIONALE: In 2020 the U.S. saw a firearm purchasing surge that was synchronous with the onset of the SARS-CoV-2 (COVID-19) pandemic and notable community unrest. Extant literature has highlighted a potential cohort effect among 2020 firearm purchasers and...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news
We thank Dr Brown for her interest in our commentary regarding SARS-CoV-2 vaccination in children under the age of 12 years and for sharing the epidemiological data relating to the COVID-19 pandemic in England and Wales. Dr Brown reported a contrast with the path taken by England and Wales in recent months compared with other European areas.
Source: The Journal of Pediatrics - Category: Pediatrics Authors: Tags: Letters to the Editor Source Type: research
In conclusion, we consider pregnant women a high-risk group of patients towards a possible SARS-CoV-2 infection, especially those who present with conditions such as gestational hypertension or obesity; moreover, we think that SARS-CoV-2 infection could increase the possibilities of having an abruptio placentae, although this result was found in only a few women, so it requires further confirmation.
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the ongoing coronavirus disease 2019 (COVID-19) pandemic. Understanding the influence of mutations in the SARS-CoV-2 gene on clinical outcomes is critical for treatment and prevention. Here, we analyzed all high-coverage complete SARS-CoV-2 sequences from GISAID database from January 1, 2020, to January 1, 2021, to mine the mutation hotspots associated with clinical outcome and developed a model to predict the clinical outcome in different epidemic strains. Exploring the cause of mutation based on RNA-dependent RNA polymerase (RdRp) and RNA-editin...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Int J Biol Macromol. 2021 Oct 14:S0141-8130(21)02156-5. doi: 10.1016/j.ijbiomac.2021.10.015. Online ahead of print.ABSTRACTSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent responsible for the Coronavirus disease-2019 (COVID-19) pandemic, has infected over 185 million individuals across 200 countries since December 2019 resulting in 4.0 million deaths. While COVID-19 is primarily associated with respiratory illnesses, an increasing number of clinical reports indicate that severely ill patients often develop thrombotic complications that are associated with increased mortality. As a consequen...
Source: International Journal of Biological Macromolecules - Category: Biochemistry Authors: Source Type: research
CONCLUSION: The study results suggest that COVID-19 stigma may contribute to burnout among physicians and nurses, and this relation may not vary across clinical roles and experiences but profession.PMID:34654583 | DOI:10.1016/j.jfma.2021.09.022
Source: J Formos Med Assoc - Category: General Medicine Authors: Source Type: research
CONCLUSIONS: Unlike COVID-19 in adult patients with kidney disease, in our cohort of children and young adults, COVID-19 incidence was similar to the general population and all cases were mild. It may be unnecessary to impose severe restrictions on this patient population during the pandemic.PMID:34655034 | DOI:10.1007/s40620-021-01171-2
Source: Journal of Nephrology - Category: Urology & Nephrology Authors: Source Type: research
J Rheumatol. 2021 Oct 15:jrheum.210534. doi: 10.3899/jrheum.210534. Online ahead of print.ABSTRACTIn the current SARS Cov-2 pandemic context, vaccination using mRNA Covid-19 vaccine has started in France in December 2020. Based on the risk for severe COVID-19, patients suffering from autoimmune diseases (AID) and receiving -or about to receive- steroids or immunosuppressive drugs have been prioritized for vaccination (1).PMID:34654731 | DOI:10.3899/jrheum.210534
Source: Journal of Rheumatology - Category: Rheumatology Authors: Source Type: research
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