The Beneficial Role of Enhanced γδ T-Cells Reconstitution after Allo-SCT in MRD+ AML

Acute myeloid leukemia (AML) patients with high-risk disease benefit from allogeneic hematopoietic stem cell transplantation (allo-SCT) as consolidation therapy. Despite exhibiting a higher risk of non-relapse mortality (NRM) than conventional chemotherapy, allo-transplanted patients experience lower relapse rates due to the pre-transplantation conditioning regimen with high doses of chemotherapy/radiotherapy and to the infusion of donor T-cells within the graft, that mediate graft-versus-leukemia (GvL) effect [1].
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Tags: The Bottom Line Source Type: research