Applications of Multi-omics Approaches for Exploring the Molecular Mechanism of Ovarian Carcinogenesis

Ovarian cancer ranks as the fifth most common cause of cancer-related death in females. The molecular mechanisms of ovarian carcinogenesis need to be explored in order to identify effective clinical therapies for ovarian cancer. Recently, multi-omics approaches have been applied to determine the mechanisms of ovarian oncogenesis at genomics (DNA), transcriptomics (RNA), proteomics (proteins), and metabolomics (metabolites) levels. Multi-omics approaches can identify some diagnostic and prognostic biomarkers and therapeutic targets for ovarian cancer, and these molecular signatures are beneficial for clarifying the development and progression of ovarian cancer. Moreover, the discovery of molecular signatures and targeted therapy strategies could noticeably improve the prognosis of ovarian cancer patients.
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research

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Am J Physiol Lung Cell Mol Physiol. 2021 Oct 20. doi: 10.1152/ajplung.00200.2021. Online ahead of print.ABSTRACTThe proton-sensing receptor, ovarian cancer G protein-coupled receptor (OGR1) has been shown to be expressed in airway smooth muscle (ASM) cells and capable of promoting ASM contraction in response to decreased extracellular pH. OGR1 knockout mice (OGR1KO) are reported to be resistant to asthma features induced by inhaled allergen. We recently described certain benzodiazepines as OGR1 activators capable of mediating both pro-contractile and pro-relaxant signaling in ASM cells. Here we assess the effect of treatme...
Source: Am J Physiol Lung Ce... - Category: Respiratory Medicine Authors: Source Type: research
British Journal of Cancer, Published online: 20 October 2021; doi:10.1038/s41416-021-01576-7Identifying causality, genetic correlation, priority and pathways of large-scale complex exposures of breast and ovarian cancers
Source: British Journal of Cancer - Category: Cancer & Oncology Authors: Source Type: research
ConclusionsBased on our results, PBM at age 30 plus PBSO between age 30 and 40 prolongs life and is cost effective in women with BRCA-1/2 mutations in Germany. Serial preventive surgeries with delayed PBSO potentially improve quality of life for women. We therefore suggest that efforts should be directed to carefully and thoroughly inform women with BRCA-1/2 mutations about their options to prevent breast and ovarian cancer.Key messagesProphylactic mastectomy at age 30 combined with prophylactic oophorectomy between age 30 and 40 may prolong lives and be cost effective in German women with BRCA- 1/2 mutations.Women ’...
Source: The European Journal of Public Health - Category: General Medicine Source Type: research
ConclusionsThis study sought to explore the perceptions of Black African women on barriers and facilitators to genetic testing to enable researchers to implement efficient intervention that would increase genetic testing attendance whilst addressing the other barriers and facilitators to alter Black African's women health seeking behaviours.Key messagesIdentify barriers and facilitators to genetic testing amongst Black African women in the UK.This study highlights the need for further research into health seeking behaviour among Black women that could contribute to the low uptake of genetic testing.
Source: The European Journal of Public Health - Category: General Medicine Source Type: research
ConclusionICI score is an effective prognosis-related biomarker for OC and can provide valuable information on the potential response to immunotherapy.
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
AbstractWomen attending mammography screening may benefit from family history (FH) assessment for the identification of Hereditary Breast Ovarian Cancer (HBOC). Few studies explored the efficacy of tailored educational interventions in driving the attention on FH-associated risk among these women. To compare the efficacy of two educational tools in increasing attention towards FH, 6.802 women with a negative mammography were randomized to receive a note on FH of breast/ovarian cancer (letter A, n  = 3.402) or a note with details on possible implication of FH patterns (letter B, n = 3.200). Upon ...
Source: Familial Cancer - Category: Cancer & Oncology Source Type: research
This study provides valuable insights into the development of a molecular-targeted photochemical strategy to improve the anti-metastatic effects of EP4 receptor antagonists.
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
Source: Cancer Management and Research - Category: Cancer & Oncology Tags: Cancer Management and Research Source Type: research
BJOG. 2021 Oct 19. doi: 10.1111/1471-0528.16978. Online ahead of print.ABSTRACTRoutine BRCA1/2 sequencing in ovarian cancer patients has come a long way since referrals to clinical genetics for sequencing were based upon the often imperfect assessment of family history in a gynaecological surgery or medical oncology clinic and the subsequent determination that the risk of an underlying genetic abnormality was above a particular threshold (often 10%).PMID:34665910 | DOI:10.1111/1471-0528.16978
Source: BJOG : An International Journal of Obstetrics and Gynaecology - Category: OBGYN Authors: Source Type: research
Int J Oncol. 2021 Nov;59(5):93. doi: 10.3892/ijo.2021.5273. Epub 2021 Oct 19.ABSTRACTThe Nectin cell adhesion molecule (Nectin) family members are Ca2+‑independent immunoglobulin‑like cellular adhesion molecules (including Nectins 1‑4), involved in cell adhesion via homophilic/heterophilic interplay. In addition, the Nectin family plays a significant role in enhancing cellular viability and movement ability. In contrast to enrichment of Nectins 1‑3 in normal tissues, Nectin‑4 is particularly overexpressed in a number of tumor types, including breast, lung, urothelial, colorectal, pancreatic and ovarian cancer. Mo...
Source: International Journal of Oncology - Category: Cancer & Oncology Authors: Source Type: research
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