Where Do Pancreatic Neuroendocrine Tumors Metastasize?

Title: Where Do Pancreatic Neuroendocrine Tumors Metastasize?Category: Diseases and ConditionsCreated: 9/23/2021 12:00:00 AMLast Editorial Review: 9/23/2021 12:00:00 AM
Source: MedicineNet Cancer General - Category: Cancer & Oncology Source Type: news

Related Links:

PANCREATIC cancer develops when cancerous cells in the pancreas - an organ in the top part of your tummy - divide and multiply uncontrollably. One telltale sign of this process can surface immediately after having a poo.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
If the current trend continues, researchers say pancreatic cancer among women aged 15 to 34 could grow to 400% of that experienced by men of the same ages by 2040.
Source: WebMD Health - Category: Consumer Health News Source Type: news
Might dietary intake of specific forms of vitamin K reduce the risk of pancreatic cancer?American Journal of Epidemiology
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Internal Medicine Journal Article Source Type: news
A patient initially diagnosed as having central serous chorioretinopathy (CSC) presented to a clinic with recurrence of pancreatic cancer manifesting as choroidal metastasis. He was initially diagnosed with CSC by a local ophthalmologist 8 weeks earlier and subsequently presented to our clinic for second opinion after further loss of vision. His medical history was significant for locally advanced pancreatic cancer that was resected by pancreaticoduodenectomy and was treated with adjuvant Folfirinox chemotherapy that was completed 12 months earlier. On examination, there was a large serous retinal detachment overlying a la...
Source: Case Reports in Ophthalmology - Category: Opthalmology Source Type: research
Pancreatic cancer (PC) is a highly malignant disease characterized by insidious onset, rapid progress, and poor therapeutic effects. The molecular mechanisms associated with PC initiation and progression are largely insufficient, hampering the exploitation of novel diagnostic biomarkers and development of efficient therapeutic strategies. Emerging evidence recently reveals that noncoding RNAs (ncRNAs), including long ncRNAs (lncRNAs) and microRNAs (miRNAs), extensively participate in PC pathogenesis. Specifically, lncRNAs can function as competing endogenous RNAs (ceRNAs), competitively sequestering miRNAs, therefore modul...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
AbstractPancreatic cancer (PC) is one of the most lethal human solid malignancies with devastating prognosis, making biomarker detection considerably important. Immune infiltrates in microenvironment is associated with patients ’ survival in PC. The role of Tropomyosin 4 (TPM4) gene in PC has not been reported. Our study first identifies TPM4 expression and its potential biological functions in PC. The potential oncogenic roles of TPM4 was examined using the datasets of TCGA (The cancer genome atlas) and GEO (Gene expres sion omnibus). We investigated the clinical significance and prognostic value of TPM4 gene based ...
Source: Investigational New Drugs - Category: Drugs & Pharmacology Source Type: research
In this study, chemopreventive effects of O-Hexadecyl- γ-glutamyl-S-benzyl-cysteinyl-D-phenyl glycine-Ethylester (HGBPE), which we previously synthesized to inhibit GSTP1 activity, was analyzed for its effect on the prevention of a rat pancreatic carcinogenesis model induced by 7,12-dimethyl-benzanthracene (DMBA). Rats administered with DMBA were group ed into five cohorts. In the treated group I, which was treated neither with HGBPE nor vehicle, sequential appearance of precancerous lesions, ductal complexes, and adenocarcinoma was confirmed as previously reported. We also confirmed in this group that mutations of K...
Source: Investigational New Drugs - Category: Drugs & Pharmacology Source Type: research
This study uses data from the Surveillance Epidemiology and End Results database to perform an age- and sex-specific time trend analysis of pancreatic cancer incidence rates in US adults.
Source: JAMA - Journal of the American Medical Association - Category: General Medicine Source Type: research
iane J. Bruns Felix C. Popp In pancreatic ductal adenocarcinoma (PDAC), the tumor stroma constitutes most of the cell mass and contributes to therapy resistance and progression. Here we show a hitherto unknown metabolic cooperation between pancreatic stellate cells (PSCs) and tumor cells through Interleukin 17B/Interleukin 17B receptor (IL-17B/IL-17RB) signaling. Tumor-derived IL-17B carrying extracellular vesicles (EVs) activated stromal PSCs and induced the expression of IL-17RB. PSCs increased oxidative phosphorylation while reducing mitochondrial turnover. PSCs activated tumor cells in a feedback loop. Tumor cell...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
ra Yu Takahashi To achieve curative resection for pancreatic cancer during pancreaticoduodenectomy (PD), extensive portal vein (PV) resection, including porto-mesenterico-splenic confluence (PMSC), may sometimes be necessary if the tumor is close to the portal venous system. Recently, this extended resection has been widely accepted in high-volume centers for pancreatic resection due to its favorable outcomes compared with non-operative treatment. However, in patients with long-term survival, sinistral portal hypertension (SPH) occurs as a late-onset postoperative complication. These patients present gastrointestinal...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research
More News: Brain | Cancer | Cancer & Oncology | Neurology | Pancreas | Pancreatic Cancer