Synthesis of a Tridecasaccharide Lipooligosaccharide Antigen from the Opportunistic Pathogen Mycobacterium kansasii

This report describes the first syntheses related to M. kansasii LOSs and 2 is the most complex mycobacterial LOS glycan to be synthesized to date when considering size and number of unique monosaccharides and glycosidic linkages. These studies not only provide a roadmap for the preparation of additional members of this family of glycans, but also provides a valuable probe for use in structure-activity relationship investigations.PMID:34553821 | DOI:10.1002/anie.202111549
Source: Angewandte Chemie - Category: Chemistry Authors: Source Type: research