A photo-responsive chemical modulation of m < sup > 6 < /sup > A RNA demethylase FTO

Chem Commun (Camb). 2021 Sep 23. doi: 10.1039/d1cc04091j. Online ahead of print.ABSTRACTThe adenine N6-methylation m6A is a crucial modification that is associated with several biological functions. One of the two m6A demethylases FTO has arisen as an attractive target for the development of novel cancer therapies. Here, we describe a new design, synthesis and evaluation of a photo-responsive and selective inhibitor of FTO.PMID:34553720 | DOI:10.1039/d1cc04091j
Source: Chemical Communications - Category: Chemistry Authors: Source Type: research