A novel role for RNF126 in the promotion of G2 arrest via interaction with 14-3-3 σ

Cell cycle checkpoints and DNA repair are important for cell survival after exogenous DNA damage. Both rapid blockage of G2 to M phase transition in the cell cycle and the maintenance of relatively slow G2 arrest are critical in order to protect cells from lethal ionizing radiation (IR). Checkpoint kinase 1 (CHK1) is pivotal in blocking the transition from G2 to M phases in response to IR. The 14-3-3 σ protein is important for IR-induced G2 arrest maintenance in which p53-dependent 14-3-3σ transcription is involved.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: Biology Contribution Source Type: research